UniProt Accession

 ADH4_HUMAN; P08319; A8K470; B4DIE7; C9J4A9; Q8TCD7 

Genbank Protein ID

 M15943; X56411; X56412; X56413; X56414; X56415; X56416; X56417; X56418; X56419; AK290835; AK295556; AY974245; AC019131; AP002026; BC022319 

Genbank Nucleotide ID

 AAA51595.1; CAA39813.1; CAA39813.1; CAA39813.1; CAA39813.1; CAA39813.1; CAA39813.1; CAA39813.1; CAA39813.1; CAA39813.1; BAF83524.1; BAG58459.1; AAX59034.1; AAH22319.1 

Protein Name

 Alcohol dehydrogenase 4 

Protein Synonyms/Alias

 Alcohol dehydrogenase class II pi chain 

Gene Name

 ADH4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
254	LNPRDLHKPIQEVII	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 NP_BIND 48 49 NAD.
 NP_BIND 205 210 NAD.
 NP_BIND 298 300 NAD.
 NP_BIND 323 325 NAD.
 METAL 47 47 Zinc 1; catalytic.
 METAL 69 69 Zinc 1; catalytic.
 METAL 99 99 Zinc 2.
 METAL 102 102 Zinc 2.
 METAL 105 105 Zinc 2.
 METAL 113 113 Zinc 2.
 METAL 180 180 Zinc 1; catalytic.
 BINDING 229 229 NAD.
 BINDING 234 234 NAD.
 BINDING 375 375 NAD.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 380 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IDA:UniProtKB.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IEA:Compara.
 GO:0005503; F:all-trans retinal binding; IDA:UniProtKB.
 GO:0019115; F:benzaldehyde dehydrogenase activity; IDA:UniProtKB.
 GO:0051287; F:NAD binding; IDA:UniProtKB.
 GO:0003960; F:NADPH:quinone reductase activity; ISS:UniProtKB.
 GO:0019841; F:retinol binding; IDA:UniProtKB.
 GO:0004745; F:retinol dehydrogenase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0046164; P:alcohol catabolic process; ISS:UniProtKB.
 GO:0006081; P:cellular aldehyde metabolic process; IDA:UniProtKB.
 GO:0006069; P:ethanol oxidation; IDA:UniProtKB.
 GO:0042375; P:quinone cofactor metabolic process; ISS:UniProtKB.
 GO:0042572; P:retinol metabolic process; IDA:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS