| Tag | Content |
|---|
| CPLM ID | CPLM-017385 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein phosphatase 1K, mitochondrial |
Protein Synonyms/Alias | PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa |
Gene Name | PPM1K |
Gene Synonyms/Alias | PP2CM |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 270 | SIGDLDLKTSGVIAE | ubiquitination | [1] | | 281 | VIAEPETKRIKLHHA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. |
Sequence Annotation | DOMAIN 93 346 PP2C-like.
METAL 127 127 Magnesium.
METAL 128 128 Magnesium; via carbonyl oxygen.
METAL 337 337 Magnesium. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Polymorphism; Protein phosphatase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 372 AA |
Protein Sequence | MSTAALITLV RSGGNQVRRR VLLSSRLLQD DRRVTPTCHS STSEPRCSRF DPDGSGSPAT 60
WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASQ IGKRKENEDR FDFAQLTDEV 120
LYFAVYDGHG GPAAADFCHT HMEKCIMDLL PKEKNLETLL TLAFLEIDKA FSSHARLSAD 180
ATLLTSGTTA TVALLRDGIE LVVASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 240
GGFVAWNSLG QPHVNGRLAM TRSIGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300
NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNST AVVVPFGAWG KYKNSEINFS 360
FSRSFASSGR WA 372 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:HPA. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro. GO:0006470; P:protein dephosphorylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |