UniProt Accession

 NDUS6_MOUSE; P52503; Q5M9J7 

Genbank Protein ID

 BC086933; L38438 

Genbank Nucleotide ID

 AAH86933.1; AAB64010.1 

Protein Name

 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 

Protein Synonyms/Alias

 Complex I-13kD-A; CI-13kD-A; NADH-ubiquinone oxidoreductase 13 kDa-A subunit 

Gene Name

 Ndufs6 

Gene Synonyms/Alias

 Ip13 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	TGQVYDEKDYRRVRF	acetylation	[1]
90	GGALGHPKVYINLDK	acetylation	[1, 2, 3]
97	KVYINLDKETKTGTC	acetylation	[1, 4]
112	GYCGLQFKQHHH***	acetylation	[1, 2, 3, 4, 5]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [5] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 MOD_RES 112 112 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0072358; P:cardiovascular system development; IMP:MGI.
 GO:0006631; P:fatty acid metabolic process; IMP:MGI.
 GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0010259; P:multicellular organismal aging; IMP:MGI.
 GO:0006936; P:muscle contraction; IMP:MGI.
 GO:0061458; P:reproductive system development; IMP:MGI.
 GO:0022904; P:respiratory electron transport chain; IMP:MGI. 

Interpro

 IPR016668; NADH_Ub_cplx-1_Fe-S_6_mit.
 IPR019401; Znf_CHCC. 

Pfam

 PF10276; zf-CHCC 

SMART

  

PROSITE

  

PRINTS