UniProt Accession

 NFYB_HUMAN; P25208; A8K7B9; Q96IY8 

Genbank Protein ID

 L06145; X59710; AK291934; CH471054; BC005316; BC005317; BC007035 

Genbank Nucleotide ID

 AAA59930.1; CAA42230.1; BAF84623.1; EAW97740.1; AAH05316.1; AAH05317.1; AAH07035.1 

Protein Name

 Nuclear transcription factor Y subunit beta 

Protein Synonyms/Alias

 CAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YB 

Gene Name

 NFYB 

Gene Synonyms/Alias

 HAP3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
140	PLKLYLQKFREAMKG	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. 

Sequence Annotation

 DNA_BIND 59 65 By similarity.
 REGION 1 52 A domain.
 REGION 53 142 B domain.
 REGION 86 97 Subunit association domain (SAD) (By
 REGION 143 207 C domain.
 CROSSLNK 140 140 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 207 AA 

Protein Sequence

Gene Ontology

 GO:0016602; C:CCAAT-binding factor complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003958; CBFA_NFYB_domain.
 IPR009072; Histone-fold.
 IPR003957; Transcrpt_fac_CBFA/NFYB_topo.
 IPR003956; Transcrpt_fac_NFYB/HAP3_CS. 

Pfam

 PF00808; CBFD_NFYB_HMF 

SMART

  

PROSITE

 PS00685; NFYB_HAP3 

PRINTS

 PR00615; CCAATSUBUNTA.