UniProt Accession

 ADA_RAT; Q920P6 

Genbank Protein ID

 AB059655; BC088116 

Genbank Nucleotide ID

 BAB69691.1; AAH88116.1 

Protein Name

 Adenosine deaminase 

Protein Synonyms/Alias

 Adenosine aminohydrolase 

Gene Name

 Ada 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
33	TILYYGKKRGIDLPA	acetylation	[1]
54	RNIIGMDKPLSLPDF	acetylation	[1]
284	THAVVRFKDDQANYS	acetylation	[1]
312	DTDYQMVKKDMGFTE	acetylation	[1]
323	GFTEEEFKRLNINAA	acetylation	[1]
341	FLPEDEKKELLERLY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (By similarity). 

Sequence Annotation

 ACT_SITE 217 217 Proton donor (By similarity).
 METAL 15 15 Zinc; catalytic (By similarity).
 METAL 17 17 Zinc; catalytic (By similarity).
 METAL 214 214 Zinc; catalytic (By similarity).
 METAL 295 295 Zinc; catalytic (By similarity).
 BINDING 17 17 Substrate (By similarity).
 BINDING 19 19 Substrate (By similarity).
 BINDING 184 184 Substrate; via amide nitrogen and
 BINDING 296 296 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 54 54 N6-acetyllysine (By similarity).
 MOD_RES 232 232 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Hydrolase; Membrane; Metal-binding; Nucleotide metabolism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 352 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0060205; C:cytoplasmic membrane-bounded vesicle lumen; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0032839; C:dendrite cytoplasm; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IBA:RefGenome.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0004000; F:adenosine deaminase activity; ISS:UniProtKB.
 GO:0001883; F:purine nucleoside binding; IDA:RGD.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0006154; P:adenosine catabolic process; ISS:UniProtKB.
 GO:0007568; P:aging; IEP:RGD.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0046061; P:dATP catabolic process; IEA:Compara.
 GO:0006157; P:deoxyadenosine catabolic process; IEA:Compara.
 GO:0048566; P:embryonic digestive tract development; IEA:Compara.
 GO:0002314; P:germinal center B cell differentiation; IEA:Compara.
 GO:0001821; P:histamine secretion; IMP:RGD.
 GO:0043103; P:hypoxanthine salvage; IBA:RefGenome.
 GO:0046103; P:inosine biosynthetic process; ISS:UniProtKB.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0048286; P:lung alveolus development; IEA:Compara.
 GO:0060169; P:negative regulation of adenosine receptor signaling pathway; IBA:RefGenome.
 GO:0042323; P:negative regulation of circadian sleep/wake cycle, non-REM sleep; IMP:RGD.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0002686; P:negative regulation of leukocyte migration; IEA:Compara.
 GO:0002906; P:negative regulation of mature B cell apoptotic process; IEA:Compara.
 GO:0070256; P:negative regulation of mucus secretion; IEA:Compara.
 GO:0060407; P:negative regulation of penile erection; IEA:Compara.
 GO:0070244; P:negative regulation of thymocyte apoptotic process; IEA:Compara.
 GO:0048541; P:Peyer's patch development; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Compara.
 GO:0030890; P:positive regulation of B cell proliferation; IEA:Compara.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0002636; P:positive regulation of germinal center formation; IEA:Compara.
 GO:0010460; P:positive regulation of heart rate; IEA:Compara.
 GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Compara.
 GO:0033089; P:positive regulation of T cell differentiation in thymus; IEA:Compara.
 GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0032261; P:purine nucleotide salvage; IEA:Compara.
 GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
 GO:0033632; P:regulation of cell-cell adhesion mediated by integrin; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0001666; P:response to hypoxia; IMP:RGD.
 GO:0043278; P:response to morphine; IMP:RGD.
 GO:0033197; P:response to vitamin E; IDA:RGD.
 GO:0042110; P:T cell activation; IBA:RefGenome.
 GO:0001829; P:trophectodermal cell differentiation; IEA:Compara.
 GO:0046111; P:xanthine biosynthetic process; IEA:Compara. 

Interpro

 IPR006650; A/AMP_deam_AS.
 IPR001365; A/AMP_deaminase_dom.
 IPR006330; Ado/ade_deaminase. 

Pfam

 PF00962; A_deaminase 

SMART

  

PROSITE

 PS00485; A_DEAMINASE 

PRINTS