Tag | Content |
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CPLM ID | CPLM-024210 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 3 subunit J |
Protein Synonyms/Alias | eIF3j; Eukaryotic translation initiation factor 3 subunit 1; eIF-3-alpha; eIF3 p35 |
Gene Name | Eif3j |
Gene Synonyms/Alias | Eif3s1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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118 | PEEQLADKLRLKKLQ | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA (By similarity). |
Sequence Annotation | REGION 1 70 Sufficient for interaction with EIF3B (By REGION 244 259 Promotes stable association with the 40S MOD_RES 12 12 Phosphoserine (By similarity). MOD_RES 14 14 Phosphoserine (By similarity). MOD_RES 21 21 Phosphoserine (By similarity). MOD_RES 110 110 Phosphothreonine (By similarity). MOD_RES 128 128 Phosphoserine (By similarity). MOD_RES 255 255 Phosphotyrosine (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 259 AA |
Protein Sequence | MAAAAAAAAG DSDSWDADTF SMEDPVRKVA GGGTAGGDRW EGEDEDEDVK DNWDDDDDEN 60 KEEAEVKPEV KISEKKKIAE KIKEKERQQK KRQEEIKKRL EEPEESKVLT PEEQLADKLR 120 LKKLQEESDL ELAKETFGVN NTVYGIDAMN PSSRDDFTEF GKLLKDKITQ YEKSLYYASF 180 LEALVRDVCI SLEIDDLKKI TNSLTVLCSE KQKQEKQSKA KKKKKGVVPG GGLKATMKDD 240 LADYGGYDGG YVQDYEDFM 259 |
Gene Ontology | GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP. GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP. GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB. GO:0003743; F:translation initiation factor activity; IEA:HAMAP. GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP. GO:0006446; P:regulation of translational initiation; IEA:HAMAP. |
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