CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005535
UniProt Accession
Genbank Protein ID
 M80550 
Genbank Nucleotide ID
Protein Name
 Adenylate cyclase type 2 
Protein Synonyms/Alias
 ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2 
Gene Name
 Adcy2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
838FLWKNKFKKEREEIEubiquitination[1]
839LWKNKFKKEREEIETubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. 
Sequence Annotation
 METAL 294 294 Magnesium 1 (By similarity).
 METAL 294 294 Magnesium 2 (By similarity).
 METAL 295 295 Magnesium 2; via carbonyl oxygen (By
 METAL 338 338 Magnesium 1 (By similarity).
 METAL 338 338 Magnesium 2 (By similarity).
 CARBOHYD 712 712 N-linked (GlcNAc...) (Potential).
 CARBOHYD 717 717 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; ATP-binding; cAMP biosynthesis; Complete proteome; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1090 AA 
Protein Sequence
MRRRRYLRDR AEAAAAAAAG GGEGLQRSRD WLYESYYCMS QQHPLIVFLL LIVMGACLAL 60
LAVFFALGLE VEDHVAFLIT VPTALAIFFA IFILVCIESV FKKLLRVFSL VIWICLVAMG 120
YLFMCFGGTV SAWDQVSFFL FIIFVVYTML PFNMRDAIIA SILTSSSHTI VLSVYLSATP 180
GAKEHLFWQI LANVIIFICG NLAGAYHKHL MELALQQTYR DTCNCIKSRI KLEFEKRQQE 240
RLLLSLLPAH IAMEMKAEII QRLQGPKAGQ MENTNNFHNL YVKRHTNVSI LYADIVGFTR 300
LASDCSPGEL VHMLNELFGK FDQIAKENEC MRIKILGDCY YCVSGLPISL PNHAKNCVKM 360
GLDMCEAIKK VRDATGVDIN MRVGVHSGNV LCGVIGLQKW QYDVWSHDVT LANHMEAGGV 420
PGRVHISSVT LEHLNGAYKV EEGDGEIRDP YLKQHLVKTY FVINPKGERR SPQHLFRPRH 480
TLDGAKMRAS VRMTRYLESW GAAKPFAHLH HRDSMTTENG KISTTDVPMG QHNFQNRTLR 540
TKSQKKRFEE ELNERMIQAI DGINAQKQWL KSEDIQRISL LFYNKNIEKE YRATALPAFK 600
YYVTCACLIF LCIFIVQILV LPKTSILGFS FGAAFLSLIF ILFVCFAGQL LQCSKKASTS 660
LMWLLKSSGI IANRPWPRIS LTIVTTAIIL TMAVFNMFFL SNSEETTLPT ANTSNANVSV 720
PDNQASILHA RNLFFLPYFI YSCILGLISC SVFLRVNYEL KMLIMMVALV GYNTILLHTH 780
AHVLDAYSQV LFQRPGIWKD LKTMGSVSLS IFFITLLVLG RQSEYYCRLD FLWKNKFKKE 840
REEIETMENL NRVLLENVLP AHVAEHFLAR SLKNEELYHQ SYDCVCVMFA SIPDFKEFYT 900
ESDVNKEGLE CLRLLNEIIA DFDDLLSKPK FSGVEKIKTI GSTYMAATGL SAIPSQEHAQ 960
EPERQYMHIG TMVEFAYALV GKLDAINKHS FNDFKLRVGI NHGPVIAGVI GAQKPQYDIW 1020
GNTVNVASRM DSTGVLDKIQ VTEETSLILQ TLGYTCTCRG IINVKGKGDL KTYFVNTEMS 1080
RSLSQSNLAS 1090 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IDA:BHF-UCL.
 GO:0045121; C:membrane raft; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0008179; F:adenylate cyclase binding; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008294; F:calcium- and calmodulin-responsive adenylate cyclase activity; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046982; F:protein heterodimerization activity; IDA:BHF-UCL.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR009398; Adenylate_cyclase-like. 
Pfam
 PF06327; DUF1053
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS