UniProt Accession

 GLRX3_RAT; Q9JLZ1; Q5RK11 

Genbank Protein ID

 AF118651; BC086381 

Genbank Nucleotide ID

 AAF28843.1; AAH86381.1 

Protein Name

 Glutaredoxin-3 

Protein Synonyms/Alias

 PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2 

Gene Name

 Glrx3 

Gene Synonyms/Alias

 Picot; Txnl2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
255	ASVMLFMKGNKQEAK	acetylation	[1]
324	LDIVKELKDNGELLP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. 

Sequence Annotation

 DOMAIN 2 119 Thioredoxin.
 DOMAIN 144 238 Glutaredoxin 1.
 DOMAIN 239 337 Glutaredoxin 2.
 METAL 161 161 Iron-sulfur (2Fe-2S); shared with dimeric
 METAL 263 263 Iron-sulfur (2Fe-2S); shared with dimeric
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0005080; F:protein kinase C binding; IDA:RGD.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara. 

Interpro

 IPR002109; Glutaredoxin.
 IPR004480; Monothiol_GRX-rel.
 IPR012336; Thioredoxin-like_fold.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00462; Glutaredoxin
 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS51354; GLUTAREDOXIN_2
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS