UniProt Accession

 NR1D1_HUMAN; P20393; Q0P5Z4; Q15304 

Genbank Protein ID

 M24898; M24900; X55066; X55067; X72631; BC047875; BC056148; M34339; M34340 

Genbank Nucleotide ID

 AAA52335.1; AAA52332.1; CAB53540.1; AAH47875.1; AAH56148.1; AAA36561.1; AAA36562.2 

Protein Name

 Nuclear receptor subfamily 1 group D member 1 

Protein Synonyms/Alias

 Rev-erbA-alpha; V-erbA-related protein 1; EAR-1 

Gene Name

 NR1D1 

Gene Synonyms/Alias

 EAR1; HREV; THRAL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
117	SSRVSPSKSTSNITK	ubiquitination	[1]
400	VYAAPEGKAPANSPR	ubiquitination	[2, 3]
455	REVVEFAKHIPGFRD	ubiquitination	[1, 4]
576	ALRALVLKNRPLETS	ubiquitination	[1, 3, 4]
587	LETSRFTKLLLKLPD	ubiquitination	[2]
591	RFTKLLLKLPDLRTL	ubiquitination	[1, 2, 4]
605	LNNMHSEKLLSFRVD	ubiquitination	[2, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine. 

Sequence Annotation

 DNA_BIND 129 205 Nuclear receptor.
 ZN_FING 132 152 NR C4-type.
 ZN_FING 169 193 NR C4-type.  

Keyword

 3D-structure; Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 614 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0071222; P:cellular response to lipopolysaccharide; IMP:BHF-UCL.
 GO:0007623; P:circadian rhythm; IEA:Compara.
 GO:0010871; P:negative regulation of receptor biosynthetic process; IMP:BHF-UCL.
 GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 

Interpro

 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.