CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transformation/transcription domain-associated protein 
Protein Synonyms/Alias
  
Gene Name
 TRRAP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
283TWGITSCKAPGEAQFubiquitination[1]
294EAQFIPNKQLQPKETubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3588 AA 
Protein Sequence
XTLSFLAYII RIYQELVTKY SQQMVKGMLQ LLSNCPAETA HLRKELLIAA KHILTTELRN 60
QFIPCMDKLF DESILIGSGY TARETLRPLA YSTLADLVHH VRQHLPLSDL SLAVQLFAKN 120
IDDESLPSSI QTMSCKLLLN LVDCIRSKSE QESGNGRDVL MRMLEVFVLK FHTIARYQLS 180
AIFKKCKPQS ELGAVEAALP GVPTAPAAPG PAPSPAPVPA PPPPPPPPPP ATPVTPAPVP 240
PFEKQGEKDK EDKQTFQVTD CRSLVKTLVC GVKTITWGIT SCKAPGEAQF IPNKQLQPKE 300
TQIYIKLVKY AMQALDIYQV QIAGNGQTYI RVANCQTVRM KEEKEVLEHF AGVFTMMNPL 360
TFKEIFQTTV PYMVERISKN YALQIVANSF LANPTTSALF ATILVEYLLD RLPEMGSNVE 420
LSNLYLKLFK LVFGSVSLFA AENEQMLKPH LHKIVNSSME LAQTAKEPYN YFLLLRALFR 480
SIGGGSHDLL YQEFLPLLPN LLQGLNMLQS GLHKQHMKDL FVELCLTVPV RLSSLLPYLP 540
MLMDPLVSAL NGSQTLVSQG LRTLELCVDN LQPDFLYDHI QPVRAELMQA LWRTLRNPAD 600
SISHVAYRVL GKFGGSNRKM LKESQKLHYV VTEVQGPSIT VEFSDCKASL QLPMEKAIET 660
ALDCLKSANT EPYYRRQAWE VIKCFLVAMM SLEDNKHALY QLLAHPNFTE KTIPNVIISH 720
RYKAQDTPAR KTFEQALTGA FMSAVIKDLR PSALPFVASL IRHYTMVAVA QQCGPFLLPC 780
YQVGSQPSTA MFHSEENGSK GMDPLVLIDA IAICMAYEEK ELCKIGEVAL AVIFDVASII 840
LGSKERACQL PLFSYIVERL CACCYEQAWY AKLGGVVSIK FLMERLPLTW VLQNQQTFLK 900
ALLFVMMDLT GEVSNGAVAM AKTTLEQLLM RCATPLKDEE RAEEIVAAQE KSFHHVTHDL 960
VREVTSPNST VRKQAMHSLQ VLAQVTGKSV TVIMEPHKEV LQDMVPPKKH LLRHQPANAQ 1020
IGLMEGNTFC TTLQPRLFTM DLNVVEHKVF YTELLNLCEA EDSALTKLPC YKSLPSLVPL 1080
RIAALNALAA CNYLPQSREK IIAALFKALN STNSELQEAG EACMRKFLEG ATIEVDQIHT 1140
HMRPLLMMLG DYRSLTLNVV NRLTSVTRLF PNSFNDKFCD QMMQHLRKWM EVVVITHKGG 1200
QRSDGNESIS ECGRCPLSPF CQFEPAMEGV EEMKICSAII NLFHLIPAAP QTLVKPLLEV 1260
VMKTERAMLI EAGSPFREPL IKFLTRHPSQ TVELFMMEAT LNDPQWSRMF MSFLKHKDAR 1320
PLRDVLAANP NRFITLLLPG GAQTAVRPGS PSTSTMRLDL QFQAIKIISI IVKNDDSWLA 1380
SQHSLVSQLR RVWVSENFQE RHRKENMAAT NWKEPKLLAY CLLNYCKRNY GDIELLFQLL 1440
RAFTGRFLCN MTFLKEYMEE EIPKNYSIAQ KRALFFRFVD FNDPNFGDEL KAKVLQHILN 1500
PAFLYSFEKG EGEQLLGPPN PEGDNPESIT SVFITKVLDP EKQADMLDSL RIYLLQYATL 1560
LVEHAPHHIH DNNKNRNSKL RRLMTFAWPC LLSKACVDPA CKYSGHLLLA HIIAKFAIHK 1620
KIVLQVFHSL LKAHAMEARA IVRQAMAILT PAVPARMEDG HQMLTHWTRK IIVEEGHTVP 1680
QLVHILHLIV QHFKVYYPVR HHLVQHMVSA MQRLGFTPSV TIEQRRLAVD LSEVVIKWEL 1740
QRIKDQQPDS DMDPNSSGEG VNSVSSSIKR GLSVDSAQEV KRFRTATGAI SAVFGRSQSL 1800
PGADSLLAKP IDKQHTDTVV NFLIRVACQV NDNTNTAGSP GEVLSRRCVN LLKTALRPDM 1860
WPKSELKLQW FDKLLMTVEQ PNQVNYGNIC TGLEVLSFLL TVLQSPAILS SFKPLQRGIA 1920
ACMTCGNTKV LRAVHSLLSR LMSIFPTEPS TSSVASKYEE LECLYAAVGK VIYEGLTNYE 1980
KATNANPSQL FGTLMILKSA CSNNPSYIDR LISVFMRSLQ KMVREHLNPQ AASGSTEATS 2040
GTSELVMLSL ELVKTRLAVM SMEMRKNFIQ AILTSLIEKS PDAKILRAVV KIVEEWVKNN 2100
SPMAANQTPT LREKSILLVK MMTYIEKRFP EDLELNAQFL DLVNYVYRDE TLSGSELTAK 2160
LEPAFLSGLR CAQPLIRAKF FEVFDNSMKR RVYERLLYVT CSQNWEAMGN HFWIKQCIEL 2220
LLAVCEKSTP IGTSCQGAML PSITNVINLA DSHDRAAFAM VTHVKQEPRE RENSESKEED 2280
VEIDIELAPG DQTSTPKTKE LSEKDIGNQL HMLTNRHDKF LDTLREVKTG ALLSAFVQLC 2340
HISTTLAEKT WVQLFPRLWK ILSDRQQHAL AGEISPFLCS GSHQVQRDCQ PSALNCFVEA 2400
MSQCVPPIPI RPCVLKYLGK THNLWFRSTL MLEHQAFEKG LSLQIKPKQT TEFYEQESIT 2460
PPQQEILDSL AELYSLLQEE DMWAGLWQKR CKYSETATAI AYEQHGFFEQ AQESYEKAMD 2520
KAKKEHERSN ASPAIFPEYQ LWEDHWIRCS KELNQWEALT EYGQSKGHIN PYLVLECAWR 2580
VSNWTAMKEA LVQVEVSCPK EMAWKVNMYR GYLAICHPEE QQLSFIERLV EMASSLAIRE 2640
WRRLPHVVSH VHTPLLQAAQ QIIELQEAAQ INAGLQPTNL GRNNSLHDMK TVVKTWRNRL 2700
PIVSDDLSHW SSIFMWRQHH YQAIVTAYEN SSQHDPSSNN AMLGVHASAS AIIQYGKIAR 2760
KQGLVNVALD ILSRIHTIPT VPIVDCFQKI RQQVKCYLQL AGVMGKNECM QGLEVIESTN 2820
LKYFTKEMTA EFYALKGMFL AQINKSEEAN KAFSAAVQMH DVLVKAWAMW GDYLENIFVK 2880
ERQLHLGVSA ITCYLHACRH QNESKSRKYL AKVLWLLSFD DDKNTLADAV DKYCIGVPPI 2940
QWLAWIPQLL TCLVGSEGKL LLNLISQVGR VYPQAVYFPI RTLYLTLKIE QRERYKSDSG 3000
QQQPSSVGNQ SHSASDPGPI RATAPMWRCS RIMHMQRELH PTLLSSLEGI VDQMVWFREN 3060
WHEEVLRQLQ QGLAKCYSVA FEKSGAVSDA KITPHTLNFV KKLVSTFGVG LENVSNVSTM 3120
FSSAASESLA RRAQATAQDP VFQKLKGQFT TDFDFSVPGS MKLHNLISKL KKWIKILEAK 3180
TKQLPKFFLI EEKCRFLSNF SAQTAEVEIP GEFLMPKPTH YYIKIARFMP RVEIVQKHNT 3240
AARRLYIRGH NGKIYPYLVM NDACLTESRR EERVLQLLRL LNPCLEKRKE TTKRHLFFTV 3300
PRVVAVSPQM RLVEDNPSSL SLVEIYKQRC AKKGIEHDNP ISRYYDRLAT VQARGTQASH 3360
QVLRDILKEV QSNMVPRSML KEWALHTFPN ATDYWTFRKM FTIQLALIGF AEFVLHLNRL 3420
NPEMLQIAQD TGKLNVAYFR FDINDATGDL DANRPVPFRL TPNISEFLTT IGVSGPLTAS 3480
MIAVARCFAQ PNFKVDGILK TVLRDEIIAW HKKTQEDTSS PLSAAGQPEN MDSQQLVSLV 3540
QKAVTAIMTR LHNLAQFEGG ESKVNTLVAA ANSLDNLCRM DPAWHPWL 3588 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT.
 IPR011990; TPR-like_helical. 
Pfam
 PF02259; FAT
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS50290; PI3_4_KINASE_3 
PRINTS