| Tag | Content |
|---|
| CPLM ID | CPLM-008538 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Spermine synthase |
Protein Synonyms/Alias | SPMSY; Spermidine aminopropyltransferase |
Gene Name | SMS |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 98 | DSPYQNIKILHSKQF | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). |
Sequence Annotation | REGION 255 256 S-adenosylmethioninamine binding.
ACT_SITE 276 276 Proton acceptor (Probable).
BINDING 148 148 S-adenosylmethioninamine.
BINDING 177 177 Spermidine.
BINDING 201 201 Spermidine.
BINDING 220 220 S-adenosylmethioninamine.
BINDING 351 351 Spermidine.
BINDING 353 353 Spermidine.
MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Mental retardation; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 366 AA |
Protein Sequence | MAAARHSTLD FMLGAKADGE TILKGLQSIF QEQGMAESVH TWQDHGYLAT YTNKNGRLPP 60
IVRGGAIDRY WPTADGRLVE YDIDEVVYDE DSPYQNIKIL HSKQFGNILI LSGDVNLAES 120
DLAYTRAIMG SGKEDYTGKD VLILGGGDGG ILCEIVKLKP KMVTMVEIDQ MVIDGCKKYM 180
RKTCGDVLDN LKGDCYQVLI EDCIPVLKRY AKEGREFDYV INDLTAVPIS TSPEEDSTWE 240
FLRLILDLSM KVLKQDGKYF TQGNCVNLTE ALSLYEEQLG RLYCPVEFSK EIVCVPSYLE 300
LWVFYTVWKK AKP 313 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0004766; F:spermidine synthase activity; TAS:ProtInc. GO:0016768; F:spermine synthase activity; IEA:EC. GO:0006555; P:methionine metabolic process; TAS:ProtInc. GO:0006595; P:polyamine metabolic process; TAS:Reactome. GO:0006597; P:spermine biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |