CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012989
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BRISC complex subunit Abro1 
Protein Synonyms/Alias
 Abraxas brother protein 1; Protein FAM175B 
Gene Name
 Fam175b 
Gene Synonyms/Alias
 Abro1; Kiaa0157 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
187NTSQSYAKVIKEHGTubiquitination[1]
229AVCADVEKSERVVESubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex (By similarity). 
Sequence Annotation
 REGION 6 116 MPN-like (By similarity).
 MOD_RES 280 280 Phosphoserine (By similarity).
 MOD_RES 368 368 Phosphoserine (By similarity).
 MOD_RES 372 372 Phosphoserine (By similarity).
 MOD_RES 375 375 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 415 AA 
Protein Sequence
MAASISGYTF SAVCFHSANS NADHEGFLLG EVRQEETFSI SDSQISNTEF LQVIEIHNHQ 60
PCSQLFSFYD YASKVNEESL DRILKDRRKK VIGWYRFRRN TQQQMSYREQ VIHKQLTRIL 120
GVPDLVFLLF SFISTANNST HALEYVLFRP NRRYNQRISL AIPNLGNTSQ QEYKVSSVPN 180
TSQSYAKVIK EHGTDFFDKD GVMKDIRAIY QVYNALQEKV QAVCADVEKS ERVVESCQAE 240
VNKLRRQITQ KKNEKEQERR LQQALLSRQM PSESLEPAFS PRMSYSGFSA EGRSTLAETE 300
PSDPPPPYSD FHPNNQESTL SHSRMERSVF MPRPQAVGSS SYASTSGGLK FTGSGADLLP 360
SQSAAGDSGE ESDDSDYENL IDPAESPHSE YSHSKNSRPS THPDEDPRNT QTSQI 415 
Gene Ontology
 GO:0070552; C:BRISC complex; ISS:UniProtKB.
 GO:0031593; F:polyubiquitin binding; ISS:UniProtKB. 
Interpro
 IPR023238; FAM175.
 IPR023240; FAM175_BRISC_cplx_Abro1_su. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02053; BRISCABRO1.
 PR02051; PROTEINF175.