Tag | Content |
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CPLM ID | CPLM-002000 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myelin basic protein |
Protein Synonyms/Alias | MBP |
Gene Name | Mbp |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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59 | APKRGSGKDSHTRTT | ubiquitination | [1] | 74 | HYGSLPQKSQRTQDE | ubiquitination | [1] | 120 | SWGAEGQKPGFGYGG | ubiquitination | [1] |
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Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine. MOD_RES 8 8 Phosphoserine (By similarity). MOD_RES 13 13 Phosphoserine (By similarity). MOD_RES 26 26 Citrulline (By similarity). MOD_RES 32 32 Citrulline (By similarity). MOD_RES 36 36 Phosphothreonine (By similarity). MOD_RES 41 41 Phosphoserine (By similarity). MOD_RES 47 47 Phosphoserine (By similarity). MOD_RES 57 57 Phosphoserine (By similarity). MOD_RES 94 94 Phosphotyrosine (By similarity). MOD_RES 96 96 Phosphoserine (By similarity). MOD_RES 119 119 Phosphothreonine. MOD_RES 122 122 Phosphothreonine (By similarity). MOD_RES 127 127 Deamidated glutamine (By similarity). MOD_RES 131 131 Omega-N-methylarginine; alternate. MOD_RES 131 131 Symmetric dimethylarginine; alternate. MOD_RES 139 139 Phosphoserine (By similarity). MOD_RES 146 146 N6-acetyllysine (By similarity). MOD_RES 154 154 Citrulline (By similarity). MOD_RES 172 172 Deamidated glutamine (By similarity). MOD_RES 184 184 Citrulline (By similarity). MOD_RES 186 186 Phosphoserine (By similarity). MOD_RES 190 190 Phosphoserine; by UHMK1 (By similarity). MOD_RES 195 195 Citrulline (By similarity). |
Keyword | Acetylation; Alternative splicing; Autoimmune encephalomyelitis; Cell membrane; Citrullination; Complete proteome; Direct protein sequencing; Membrane; Methylation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 195 AA |
Protein Sequence | MASQKRPSQR HGSKYLATAS TMDHARHGFL PRHRDTGILD SIGRFFSGDR GAPKRGSGKD 60 SHTRTTHYGS LPQKSQRTQD ENPVVHFFKN IVTPRTPPPS QGKGRGLSLS RFSWGAEGQK 120 PGFGYGGRAS DYKSAHKGFK GAYDAQGTLS KIFKLGGRDS RSGSPMARR 169 |
Gene Ontology | GO:0043218; C:compact myelin; IDA:RGD. GO:0033269; C:internode region of axon; IEA:Compara. GO:0043025; C:neuronal cell body; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. GO:0019911; F:structural constituent of myelin sheath; IMP:RGD. GO:0061024; P:membrane organization; IEA:Compara. GO:0042552; P:myelination; IMP:RGD. GO:0050771; P:negative regulation of axonogenesis; IMP:RGD. GO:0009636; P:response to toxic substance; IEA:Compara. |
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