CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017556
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pre-mRNA-splicing factor 38A 
Protein Synonyms/Alias
  
Gene Name
 PRPF38A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MANRTVKDAHSIHGubiquitination[1]
23NPQYLVEKIIRTRIYacetylation[2]
23NPQYLVEKIIRTRIYubiquitination[1, 3, 4, 5, 6]
66GVYGGNIKPTPFLCLubiquitination[1]
97FIKNEDFKYVRMLGAubiquitination[1, 4, 6]
118GTAIDCYKYLEPLYNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 May be required for pre-mRNA splicing (Potential). 
Sequence Annotation
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 193 193 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 209 209 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MANRTVKDAH SIHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELRFVGGV 60
YGGNIKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR MLGALYMRLT GTAIDCYKYL 120
EPLYNDYRKI KSQNRNGEFE LMHVDEFIDE LLHSERVCDI ILPRLQKRYV LEEAEQLEPR 180
VSALEEDMDD VESSEEEEEE DEKLERVPSP DHRRRSYRDL DKPRRSPTLR YRRSRSRSPR 240
RRSRSPKRRS PSPRRERHRS KSPRRHRSRS RDRRHRSRSK SPGHHRSHRH RSHSKSPERS 300
KKSHKKSRRG NE 312 
Gene Ontology
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR005037; PRP38.
 IPR024767; PRP38_C. 
Pfam
 PF03371; PRP38
 PF12871; PRP38_assoc 
SMART
  
PROSITE
  
PRINTS