CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035944
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ETS-related transcription factor Elf-2 
Protein Synonyms/Alias
  
Gene Name
 ELF2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
140NTCPRYIKWTQREKGubiquitination[1, 2]
150QREKGIFKLVDSKAVubiquitination[1, 2, 3]
159VDSKAVSKLWGKHKNubiquitination[1]
167LWGKHKNKPDMNYETubiquitination[1, 2]
190YQRGILAKVEGQRLVubiquitination[1, 2, 4]
201QRLVYQFKDMPKNIVubiquitination[1]
205YQFKDMPKNIVVIDDubiquitination[1]
229LAGTTDEKSLERVSLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 245 AA 
Protein Sequence
MATSLHEGPT NQLDLLIRAV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPVEV 60
FVPPCVSTPE FIHAAMRPDV ITETVVEVST EESEPMDTSP IPTSPDSHEP MKKKKGNTTY 120
LWEFLLDLLQ DKNTCPRYIK WTQREKGIFK LVDSKAVSKL WGKHKNKPDM NYETMGRALR 180
YYYQRGILAK VEGQRLVYQF KDMPKNIVVI DDDKSETCNE DLAGTTDEKS LERVSLSAES 240
LLKAA 245 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR000418; Ets_dom.
 IPR022084; TF_Elf_N.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF12310; Elf-1_N
 PF00178; Ets 
SMART
 SM00413; ETS 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 
PRINTS
 PR00454; ETSDOMAIN.