UniProt Accession

 MED22_MOUSE; Q62276; A2ALA2; Q3TTZ9 

Genbank Protein ID

 X85169; AK144744; AK161053; AK166250; AK166474; AL773563; AL773563; BC018225 

Genbank Nucleotide ID

 CAA59453.1; BAE26044.1; BAE36173.1; BAE38661.1; BAE38795.1; CAM23699.1; CAM23700.1; AAH18225.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 22 

Protein Synonyms/Alias

 Mediator complex subunit 22; Surfeit locus protein 5; Surf-5 

Gene Name

 Med22 

Gene Synonyms/Alias

 Surf5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
38	DNFTEIIKTAKIEDE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 

Sequence Annotation

  

Keyword

 Activator; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; ISO:MGI.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro. 

Interpro

 IPR009332; Mediator_Med22. 

Pfam

 PF06179; Med22 

SMART

  

PROSITE

  

PRINTS