CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007963
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptotagmin-5 
Protein Synonyms/Alias
 Synaptotagmin IX; Synaptotagmin V; SytV 
Gene Name
 Syt5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
62CRRRMGKKSQAQAQVubiquitination[1]
75QVHLQEVKELGRSYIubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface. 
Sequence Annotation
 DOMAIN 124 211 C2 1.
 DOMAIN 253 344 C2 2.
 METAL 138 138 Calcium 2; via carbonyl oxygen (By
 METAL 139 139 Calcium 1 (By similarity).
 METAL 139 139 Calcium 2 (By similarity).
 METAL 145 145 Calcium 1 (By similarity).
 METAL 197 197 Calcium 1 (By similarity).
 METAL 197 197 Calcium 2 (By similarity).
 METAL 198 198 Calcium 1; via carbonyl oxygen (By
 METAL 199 199 Calcium 1 (By similarity).
 METAL 199 199 Calcium 2 (By similarity).
 METAL 199 199 Calcium 3 (By similarity).
 METAL 202 202 Calcium 3 (By similarity).
 METAL 205 205 Calcium 2 (By similarity).
 METAL 205 205 Calcium 3 (By similarity).
 MOD_RES 278 278 Phosphotyrosine (By similarity).  
Keyword
 Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Endosome; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 386 AA 
Protein Sequence
MFPEPPTPGS PAPETPPDSS RIRQGAVPAW VLATILLGSG LLVFSSCFCL YRKRCRRRMG 60
KKSQAQAQVH LQEVKELGRS YIDKVQPEIE ELDPSPSMPG QQVLDKHQLG RLQYSLDYDF 120
QTGQLLVGIL QAEGLAALDL GGSSDPYVSV YLLPDKRRRH ETKVHRQTLN PHFGETFAFK 180
VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVNLG RPVQAWRELQ VAPKEEQEKL 240
GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 300
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGTAVG GAGLRHWADM 360
LANPRRPIAQ WHSLRPPDRA RPIPAP 386 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0031045; C:dense core granule; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:BHF-UCL.
 GO:0030276; F:clathrin binding; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019905; F:syntaxin binding; IDA:BHF-UCL.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0017156; P:calcium ion-dependent exocytosis; NAS:RGD. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR001565; Synaptotagmin. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS
 PR00360; C2DOMAIN.
 PR00399; SYNAPTOTAGMN.