CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nucleotide exchange factor SIL1 
Protein Synonyms/Alias
  
Gene Name
 SIL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
316YAQRQFLKLGGLQVLubiquitination[1, 2, 3]
330LRTLVQEKGTEVLAVubiquitination[4]
403PEHDAREKVLQTLGVubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 468 AA 
Protein Sequence
MNSGTSLTMA PQSLPSSRMA PLGMLLGLLM AACFTFCLSH QNLEFALTNP EKSSTKETER 60
KETKAEEELD AEVLEVFHPT HEWQALQPGQ AVPAGSHVRL NLQTGEREAK LQYEDKFRNN 120
LKGKRLDINT NTYTSQDLKS ALAKFKEGAE MESSKEDKAR QAEVKRLFRP IEELKKDFDE 180
LNVVIETDMQ IMVRLINKFN SSSSSLEEKI AALFDLEYYV HQMDNAQDLL SFGGLQVVIN 240
GLNSTEPLVK EYAAFVLGAA FSSNPKVQVE AIEGGALQKL LVILATEQPL TAKKKVLFAL 300
CSLLRHFPYA QRQFLKLGGL QVLRTLVQEK GTEVLAVRVV TLLYDLVTEK MFAEEEAELT 360
QEMSPEKLQQ YRQVHLLPGL WEQGWCEITA HLLALPEHDA REKVLQTLGV LLTTCRDRYR 420
QDPQLGRTLA SLQAEYQVLA SLELQDGEDE GYFQELLGSV NSLLKELR 468 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS