UniProt Accession

 LYVE1_HUMAN; Q9Y5Y7; Q8TC18; Q9UNF4 

Genbank Protein ID

 AF118108; AF127670; AY358925; BC026231 

Genbank Nucleotide ID

 AAD42764.1; AAD49220.2; AAQ89284.1; AAH26231.1 

Protein Name

 Lymphatic vessel endothelial hyaluronic acid receptor 1 

Protein Synonyms/Alias

 LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor 

Gene Name

 LYVE1 

Gene Synonyms/Alias

 CRSBP1; HAR; XLKD1; UNQ230/PRO263 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
308	DKNPEESKSPSKTTV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. 

Sequence Annotation

 DOMAIN 40 130 Link.
 CARBOHYD 53 53 N-linked (GlcNAc...).
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 DISULFID 61 128 By similarity.
 DISULFID 85 106 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 322 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005540; F:hyaluronic acid binding; IEA:Compara.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:Compara.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0030214; P:hyaluronan catabolic process; TAS:Reactome.
 GO:0009611; P:response to wounding; TAS:ProtInc.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR000538; Link. 

Pfam

 PF00193; Xlink 

SMART

 SM00445; LINK 

PROSITE

 PS01241; LINK_1
 PS50963; LINK_2 

PRINTS

 PR01265; LINKMODULE.