UniProt Accession

 MMP1_HUMAN; P03956; P08156 

Genbank Protein ID

 X54925; X05231; M13509; U78045; BT006874; AY769434; BC013875; M16567; M15996 

Genbank Nucleotide ID

 CAA38691.1; CAA28858.1; AAA35699.1; AAB36941.1; AAP35520.1; AAV28732.1; AAH13875.1; AAA52033.1; AAA35700.1 

Protein Name

 Interstitial collagenase 

Protein Synonyms/Alias

 Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1; 22 kDa interstitial collagenase; 27 kDa interstitial collagenase 

Gene Name

 MMP1 

Gene Synonyms/Alias

 CLG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
450	RQYKFDPKTKRILTL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. 

Sequence Annotation

 REPEAT 275 324 Hemopexin 1.
 REPEAT 325 371 Hemopexin 2.
 REPEAT 374 422 Hemopexin 3.
 REPEAT 423 466 Hemopexin 4.
 REGION 98 276 Metalloprotease.
 MOTIF 90 97 Cysteine switch (By similarity).
 ACT_SITE 219 219
 METAL 92 92 Zinc 2; in inhibited form.
 METAL 124 124 Calcium 1.
 METAL 158 158 Calcium 2.
 METAL 168 168 Zinc 1.
 METAL 170 170 Zinc 1.
 METAL 175 175 Calcium 3.
 METAL 176 176 Calcium 3; via carbonyl oxygen.
 METAL 178 178 Calcium 3; via carbonyl oxygen.
 METAL 180 180 Calcium 3; via carbonyl oxygen.
 METAL 183 183 Zinc 1.
 METAL 190 190 Calcium 2; via carbonyl oxygen.
 METAL 192 192 Calcium 2; via carbonyl oxygen.
 METAL 194 194 Calcium 2.
 METAL 196 196 Zinc 1.
 METAL 198 198 Calcium 3.
 METAL 199 199 Calcium 1.
 METAL 201 201 Calcium 3.
 METAL 218 218 Zinc 2; catalytic.
 METAL 222 222 Zinc 2; catalytic.
 METAL 228 228 Zinc 2; catalytic.
 METAL 285 285 Calcium 4; via carbonyl oxygen (By
 METAL 329 329 Calcium 4; via carbonyl oxygen (By
 METAL 378 378 Calcium 4; via carbonyl oxygen (By
 METAL 427 427 Calcium 4; via carbonyl oxygen (By
 CARBOHYD 120 120 N-linked (GlcNAc...).
 DISULFID 278 466 By similarity.  

Keyword

 3D-structure; Autocatalytic cleavage; Calcium; Collagen degradation; Complete proteome; Direct protein sequencing; Disulfide bond; Extracellular matrix; Glycoprotein; Host-virus interaction; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0006508; P:proteolysis; TAS:ProtInc.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR018486; Hemopexin_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001818; Pept_M10_metallopeptidase.
 IPR021190; Pept_M10A.
 IPR016293; Pept_M10A_Metazoans.
 IPR021158; Pept_M10A_Zn_BS.
 IPR006026; Peptidase_Metallo.
 IPR002477; Peptidoglycan-bd-like. 

Pfam

 PF00045; Hemopexin
 PF00413; Peptidase_M10
 PF01471; PG_binding_1 

SMART

 SM00120; HX
 SM00235; ZnMc 

PROSITE

 PS00546; CYSTEINE_SWITCH
 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00142; ZINC_PROTEASE 

PRINTS

 PR00138; MATRIXIN.