UniProt Accession

 MSRE_MOUSE; P30204; E9QNQ5; Q923G0; Q9QZ56 

Genbank Protein ID

 L04274; L04275; D13382; AF203781; M59445; M59446; U13873; AK089178; AC111028; BC003814 

Genbank Nucleotide ID

 AAA39747.1; AAA39748.1; BAA02650.1; AAF14001.1; AAA37464.1; AAA37465.1; AAC13774.1; BAC40779.1; AAH03814.1 

Protein Name

 Macrophage scavenger receptor types I and II 

Protein Synonyms/Alias

 Macrophage acetylated LDL receptor I and II; Scavenger receptor type A; SR-A; CD204 

Gene Name

 Msr1 

Gene Synonyms/Alias

 Scvr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	DCSSESVKFDARSMT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). 

Sequence Annotation

 DOMAIN 277 350 Collagen-like.
 DOMAIN 357 457 SRCR.
 REGION 79 114 Spacer (Probable).
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 34 34 Phosphothreonine.
 MOD_RES 36 36 Phosphoserine.
 MOD_RES 40 40 Phosphoserine.
 CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
 CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
 CARBOHYD 147 147 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 253 253 N-linked (GlcNAc...) (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 DISULFID 382 446 By similarity.
 DISULFID 395 456 By similarity.
 DISULFID 426 436 By similarity.  

Keyword

 Alternative splicing; Coiled coil; Collagen; Complete proteome; Disulfide bond; Endocytosis; Glycoprotein; LDL; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 458 AA 

Protein Sequence

Gene Ontology

 GO:0005581; C:collagen; IEA:UniProtKB-KW.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030169; F:low-density lipoprotein particle binding; IMP:BHF-UCL.
 GO:0005044; F:scavenger receptor activity; IEA:InterPro.
 GO:0030301; P:cholesterol transport; IMP:BHF-UCL.
 GO:0042953; P:lipoprotein transport; IMP:MGI.
 GO:0034381; P:plasma lipoprotein particle clearance; IMP:BHF-UCL.
 GO:0010886; P:positive regulation of cholesterol storage; IMP:BHF-UCL.
 GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IGI:BHF-UCL.
 GO:0042221; P:response to chemical stimulus; IEA:Compara. 

Interpro

 IPR008160; Collagen.
 IPR003543; Macro_scav_rcpt.
 IPR001190; Srcr_rcpt.
 IPR017448; Srcr_rcpt-rel. 

Pfam

 PF01391; Collagen
 PF03523; Macscav_rec
 PF00530; SRCR 

SMART

 SM00202; SR 

PROSITE

 PS00420; SRCR_1
 PS50287; SRCR_2 

PRINTS

 PR01408; MACSCAVRCPTR.
 PR00258; SPERACTRCPTR.