CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000203
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptosomal-associated protein 23 
Protein Synonyms/Alias
 SNAP-23; Syndet; Vesicle-membrane fusion protein SNAP-23 
Gene Name
 Snap23 
Gene Synonyms/Alias
 Sndt 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
185AQNQQIQKITEKADTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion (By similarity). 
Sequence Annotation
 DOMAIN 14 76 t-SNARE coiled-coil homology 1.
 DOMAIN 145 207 t-SNARE coiled-coil homology 2.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 34 34 Phosphoserine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 112 112 Phosphoserine.
 LIPID 79 79 S-palmitoyl cysteine (By similarity).
 LIPID 80 80 S-palmitoyl cysteine (By similarity).
 LIPID 83 83 S-palmitoyl cysteine (By similarity).
 LIPID 85 85 S-palmitoyl cysteine (By similarity).
 LIPID 87 87 S-palmitoyl cysteine (By similarity).  
Keyword
 Acetylation; Cell junction; Cell membrane; Coiled coil; Complete proteome; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Protein transport; Reference proteome; Repeat; Synapse; Synaptosome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 210 AA 
Protein Sequence
MDNLSPEEVQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE QLNRIEEGMD 60
QINKDMREAE KTLTELNKCC GLCICPCNRT KNFESGKNYK ATWGDGGDNS PSNVVSKQPS 120
RITNGQPQQT TGAASGGYIK RITNDAREDE MEENLTQVGS ILGNLKNMAL DMGNEIDAQN 180
QQIQKITEKA DTNKNRIDIA NTRAKKLIDS 210 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0006887; P:exocytosis; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR000928; SNAP-25.
 IPR000727; T_SNARE_dom. 
Pfam
 PF00835; SNAP-25
 PF05739; SNARE 
SMART
 SM00397; t_SNARE 
PROSITE
 PS50192; T_SNARE 
PRINTS