CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032037
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol polyphosphate 5-phosphatase K 
Protein Synonyms/Alias
 cDNA FLJ57541, highly similar to Skeletal muscle and kidney-enriched inositol phosphatase (EC 3.1.3.56) 
Gene Name
 INPP5K 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
128CYGGLWEKDQLSIAKubiquitination[1]
136DQLSIAKKHDPLLREubiquitination[1]
156LLFPPTYKFDRNSNDubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 356 AA 
Protein Sequence
MQGILLLVFA KYQHLPYIQI LSTKSTPTGL FGYWGNKGGV NICLKLYGYY VSIINCHLPP 60
HISNNYQRLE HFDRILEMQN CEGRDIPNIL DHDLIIWFGD MNFRIEDFGL HFVRESIKNR 120
CYGGLWEKDQ LSIAKKHDPL LREFQEGRLL FPPTYKFDRN SNDYDTSEKK RKPAWTDRIL 180
WRLKRQPCAG PDTPIPPASH FSLSLRGYSS HMTYGISDHK PVSGTFDLEL KPLVSAPLIV 240
LMPEDLWTVE NDMMVSYSST SDFPSSPWDW IGLYKVGLRD VNDYVSYAWV GDSKVSCSDN 300
LNQVYIDISN IPTTEDEFLL CYYSNSLRSV VGISRPFQIP PGSLREDPLG EAQPQI 356 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IEA:Compara.
 GO:0005000; F:vasopressin receptor activity; IEA:Compara.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0035305; P:negative regulation of dephosphorylation; IEA:Compara.
 GO:2000466; P:negative regulation of glycogen (starch) synthase activity; IEA:Compara.
 GO:0045719; P:negative regulation of glycogen biosynthetic process; IEA:Compara.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Compara.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
 GO:2001153; P:positive regulation of renal water transport; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0035810; P:positive regulation of urine volume; IEA:Compara.
 GO:0072661; P:protein targeting to plasma membrane; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc. 
Pfam
 PF03372; Exo_endo_phos 
SMART
 SM00128; IPPc 
PROSITE
  
PRINTS