| Tag | Content |
|---|
| CPLM ID | CPLM-016605 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gephyrin |
Protein Synonyms/Alias | Molybdopterin adenylyltransferase; MPT adenylyltransferase; Domain G; Molybdopterin molybdenumtransferase; MPT Mo-transferase; Domain E |
Gene Name | Gphn |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | TAAALAAKIPDSIIS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
Sequence Annotation | REGION 14 153 MPT Mo-transferase.
REGION 140 349 Interaction with GABARAP (By similarity).
REGION 327 769 MPT adenylyltransferase.
MOD_RES 188 188 Phosphoserine.
MOD_RES 194 194 Phosphoserine.
MOD_RES 266 266 Phosphothreonine (By similarity).
MOD_RES 338 338 Phosphoserine. |
Keyword | ATP-binding; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Magnesium; Membrane; Metal-binding; Molybdenum; Molybdenum cofactor biosynthesis; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 769 AA |
Protein Sequence | MATEGMILTN HDHQIRVGVL TVSDSCFRNL AEDRSGINLK DLVQDPSLLG GTISAYKIVP 60
DEIEEIKETL IDWCDEKELN LILTTGGTGF APRDVTPEAT KEVIEREAPG MALAMLMGSL 120
NVTPLGMLSR PVCGIRGKTL IINLPGSKKG SQECFQFILP ALPHAIDLLR DAIVKVKEVH 180
DELEDLPSPP PPLSPPPTTS PHKQTEDKGV QCEEEEEEKK DSGVASTEDS SSSHITAAAL 240
AAKIPDSIIS RGVQVLPRDT ASLSTTPSES PRAQATSRLS TASCPTPKQI RRPDESKGVA 300
SRVGSLKARL PSCSSTYSVS EVQSRCSSKE NILRASHSAV DITKVARRHR MSPFPLTSMD 360
KAFITVLEMT PVLGTEIINY RDGMGRVLAQ DVYAKDNLPP FPASVKDGYA VRAADGPGDR 420
FIIGESQAGE QPTQTVMPGQ VMRVTTGAPI PCGADAVVQV EDTELIRESD DGTEELEVRI 480
LVQARPGQDI RPIGHDIKRG ECVLAKGTHM GPSEIGLLAT VGVTEVEVNK FPVVAVMSTG 540
NELLNPEDDL LPGKIRDSNR STLLATIQEH GYPTINLGIV GDNPDDLLNA LNEGISRADV 600
IITSGGVSMG EKDYLKQVLD IDLHAQIHFG RVFMKPGLPT TFATLDIDGV RKIIFALPGN 660
PVSAVVTCNL FVVPALRKMQ GILDPRPTII KARLSCDVKL DPRPEYHRCI LTWHHQEPLP 720
WAQSTGNQMS SRLMSMRSAN GLLMLPPKTE QYVELHKGEV VDVMVIGRL 769 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0019897; C:extrinsic to plasma membrane; TAS:MGI. GO:0005622; C:intracellular; IDA:MGI. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008092; F:cytoskeletal protein binding; TAS:MGI. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0016740; F:transferase activity; IEA:UniProtKB-KW. GO:0007529; P:establishment of synaptic specificity at neuromuscular junction; IMP:MGI. GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. |
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