Tag | Content |
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CPLM ID | CPLM-023283 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tripartite motif-containing protein 35 |
Protein Synonyms/Alias | Hemopoietic lineage switch protein 5 |
Gene Name | TRIM35 |
Gene Synonyms/Alias | HLS5; KIAA1098 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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61 | SPTCPVCKDRASPAD | ubiquitination | [1] | 138 | GHRVQPVKDTAHDFR | ubiquitination | [1] | 160 | HALREKAKAFWAMRR | ubiquitination | [1] | 174 | RSYEAIAKHNQVEAA | ubiquitination | [1] | 193 | RIRQEFDKLREFLRV | ubiquitination | [1] | 216 | MAEETRQKQLLADEK | ubiquitination | [1] | 223 | KQLLADEKMKQLTEE | ubiquitination | [1] | 225 | LLADEKMKQLTEETE | ubiquitination | [1] | 255 | DDVSFLMKHKSRKRR | ubiquitination | [1] | 257 | VSFLMKHKSRKRRLF | ubiquitination | [1] | 488 | CPLHISVKEELDG** | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity). |
Sequence Annotation | DOMAIN 284 487 B30.2/SPRY. ZN_FING 21 61 RING-type. ZN_FING 96 137 B box-type. MOD_RES 1 1 N-acetylmethionine. MOD_RES 4 4 Phosphoserine. MOD_RES 8 8 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 493 AA |
Protein Sequence | MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC 60 KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC 120 CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN MEHALREKAK AFWAMRRSYE AIAKHNQVEA 180 AWLEGRIRQE FDKLREFLRV EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER 240 LQMEMKEDDV SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE 300 SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV FSQGSHAWEV 360 ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC RTQGVEGDHC VTSDPATSPL 420 VLAIPRRLRV ELECEEGELS FYDAERHCHL YTFHARFGEV RPYFYLGGAR GAGPPEPLRI 480 CPLHISVKEE LDG 493 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0006917; P:induction of apoptosis; ISS:UniProtKB. GO:0008285; P:negative regulation of cell proliferation; IEA:Compara. GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB. |
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PRINTS | |