CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006628
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dimethylaniline monooxygenase [N-oxide-forming] 1 
Protein Synonyms/Alias
 Dimethylaniline oxidase 1; Hepatic flavin-containing monooxygenase 1; FMO 1 
Gene Name
 Fmo1 
Gene Synonyms/Alias
 Fmo-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
304VLIKPSIKEVKENSVacetylation[1]
407PPPSVMMKEVNERKKacetylation[1]
480FRLTGPGKWEGARKAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. 
Sequence Annotation
 NP_BIND 9 14 FAD (Potential).
 NP_BIND 191 196 NADP (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MVKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSCDLGGL WRFTEHVEEG RASLYNSVVS 60
NSSKEMSCYS DFPFPEDYPN FVPNSLFLEY LQLYATQFNL LRCIYFNTKV CSITKRPDFA 120
VSGQWEVVTV CQGKQSSDTF DAVMVCTGFL TNPHLPLDSF PGIQTFKGQY FHSRQYKHPD 180
VFKDKRVLVV GMGNSGTDIA VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMIFMTRFQ 240
NMLRNLLPTP VVSWLISKKM NSWFNHVNYG VAPEDRTQLR EPVLNDELPG RIITGKVLIK 300
PSIKEVKENS VVFNNTPKEE PIDVIVFATG YSFAFPFLDE SIVKVEDGQA SLYKYIFPAH 360
LPKPTLAVIG LIKPLGSMIP TGETQARWVV QVLKGATTLP PPSVMMKEVN ERKKNKHSGF 420
GLCYCKALQS DYITYIDDLL TSINAKPDLR AMLLTDPRLA LSIFFGPCTP YHFRLTGPGK 480
WEGARKAILT QWDRTVNVTK TRTVQETPST FETLLKLFSF LALLVAVFFI FL 532 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0031227; C:intrinsic to endoplasmic reticulum membrane; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IDA:RGD.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0070995; P:NADPH oxidation; IEA:Compara.
 GO:0006082; P:organic acid metabolic process; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
 GO:0006970; P:response to osmotic stress; IEP:RGD.
 GO:0009404; P:toxin metabolic process; IEA:Compara. 
Interpro
 IPR012143; DiMe-aniline_mOase.
 IPR000960; Flavin_mOase.
 IPR020946; Flavin_mOase-like.
 IPR002253; Flavin_mOase_1.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00743; FMO-like 
SMART
  
PROSITE
  
PRINTS
 PR00370; FMOXYGENASE.
 PR01121; FMOXYGENASE1.