CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metallophosphoesterase 1 
Protein Synonyms/Alias
 Post-GPI attachment to proteins factor 5 
Gene Name
 Mppe1 
Gene Synonyms/Alias
 Pgap5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
278RNVPFEEKYDVLSREubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity). 
Sequence Annotation
 METAL 75 75 Divalent metal cation 2 (By similarity).
 METAL 117 117 Divalent metal cation 1 (By similarity).
 METAL 117 117 Divalent metal cation 2 (By similarity).
 METAL 155 155 Divalent metal cation 1 (By similarity).
 METAL 249 249 Divalent metal cation 1 (By similarity).
 METAL 303 303 Divalent metal cation 1 (By similarity).
 METAL 305 305 Divalent metal cation 2 (By similarity).  
Keyword
 Alternative splicing; Complete proteome; ER-Golgi transport; Golgi apparatus; GPI-anchor biosynthesis; Hydrolase; Manganese; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MALVRWGLKR QNFHPLRRRR RALLLKLTVV IISVLLFCEY FIYYLVLFRC HWPEVKTLAH 60
GGRQEPVLKA MFLADTHLLG EIRGHWLDKL RREWQMERAF QTALWLLQPE VVFILGDIFD 120
EGKWSSDQAW ADDVQRFQRM FRHDSHVQLK VVIGNHDVGF HYQMSKYRIK RFEKVFGSER 180
LLSLKGVNFV MVNSVAMEGD GCIICSEEEA ELREISRKLN CSQEVPGSSQ CDREPEPRLP 240
LSAPVLLQHY PLYRASDANC SGEDAAPPEE RNVPFEEKYD VLSREASQKL LWWLRPRLVL 300
SGHTHSACEV LHPGGAPEVS VPSFSWRNRN NPSFIMGSLT SRDYALSKCY LPFEDTVLTM 360
YGAAAGFLMI LILVHFEHLP SPFLCGWKLC RLHMRR 396 
Gene Ontology
 GO:0005801; C:cis-Golgi network; ISS:UniProtKB.
 GO:0070971; C:endoplasmic reticulum exit site; ISS:UniProtKB.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0034235; F:GPI anchor binding; ISS:UniProtKB.
 GO:0030145; F:manganese ion binding; ISS:UniProtKB.
 GO:0008081; F:phosphoric diester hydrolase activity; ISS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB. 
Interpro
 IPR004843; Metallo_PEstase_dom. 
Pfam
 PF00149; Metallophos 
SMART
  
PROSITE
  
PRINTS