| Tag | Content |
|---|
| CPLM ID | CPLM-010518 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Stromal interaction molecule 2 |
Protein Synonyms/Alias | |
Gene Name | Stim2 |
Gene Synonyms/Alias | Kiaa1482 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 298 | MDEINYAKEEACRLR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx (By similarity). |
Sequence Annotation | DOMAIN 67 102 EF-hand.
DOMAIN 136 204 SAM.
MOD_RES 609 609 Phosphoserine (By similarity).
MOD_RES 621 621 Phosphoserine (By similarity).
MOD_RES 661 661 Phosphoserine (By similarity).
MOD_RES 680 680 Phosphoserine.
CARBOHYD 135 135 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Calcium transport; Coiled coil; Complete proteome; Endoplasmic reticulum; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 746 AA |
Protein Sequence | MLLFGLLVAG VADGCDLVPR HLRGRRASGS AGAAASPSAA AAGERQALLT DPCMSLSPPC 60
FTEEDRFSLE ALQTIHKQMD DDKDGGIEVD ESDEFIREDM KYKDATNKHS HLHREDKHIT 120
VEDLWKQWKT SEVHNWTLED TLQWLIEFVE LPQYEKNFRD NNVKGTTLPR IAVHETSFMI 180
SQLKISDRSH RQKLQLKALD VVLFGPLTRP PHNWMKDFIL TISIVIGVGG CWFAYTQNKT 240
SKEHVAKMMK DLESLQTAEQ SLMDLQERLE KAQEENRTVA VEKQNLERKM MDEINYAKEE 300
ACRLRELREG AECELSRRQY AEQELEQVRM ALKKAEKEFE LRSSWSVPDA LQKWLQLTHE 360
VEVQYYNIKR QNAEMQLAIA KDEAEKIKKK RSTVFGTLHV AHSSSLDEVD HKILEAKKAL 420
SELTTCLRER LFRWQQIEKI CGFQIAHNSG LPSLTSSLYS DHSWVVMPRV SIPPYPIAGG 480
VDDLDEDTPP IVPQFPGTVA KPAGSLARSS SLCRSRRSIV PSSPQSQRAQ LPAHAPLAAH 540
PRHPHHPQHP QHSLPSPDPD ILSVSSCPAL YRNEEEEEAI YFTAEKQWEV PDTASECDSL 600
NSSSGRKPSP PSSLEMYQTL SSRKISRDEL SLEDSSRGES PVTADVSRGS PECVGLTETK 660
SMIFSPASRV YNGILEKSCS MHQLSSGIPV PHPRHTSCSS AGNDSKPVQE ASNVSRVSSI 720
PHDLCHNGEK SKKPSKIKSL FKKKSK 746 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; ISA:MGI. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB. GO:0005509; F:calcium ion binding; ISS:UniProtKB. GO:0015279; F:store-operated calcium channel activity; ISS:UniProtKB. GO:0032237; P:activation of store-operated calcium channel activity; ISS:UniProtKB. GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB. GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |