| Tag | Content |
|---|
| CPLM ID | CPLM-022675 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acyl-coenzyme A thioesterase 3 |
Protein Synonyms/Alias | Acyl-CoA thioesterase 3; PTE-Ia; Peroxisomal acyl-coenzyme A thioester hydrolase 2a; Peroxisomal long-chain acyl-CoA thioesterase 2 |
Gene Name | Acot3 |
Gene Synonyms/Alias | Pte1a; Pte2; Pte2a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | RSVLRDEKGALFRAH | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Mainly active on long-chain acyl-CoAs. May have a function in termination of beta-oxidation of fatty acids. |
Sequence Annotation | MOTIF 430 432 Microbody targeting signal (Potential).
ACT_SITE 243 243 Charge relay system (By similarity).
ACT_SITE 337 337 Charge relay system (By similarity).
ACT_SITE 371 371 Charge relay system (By similarity). |
Keyword | Alternative splicing; Complete proteome; Hydrolase; Peroxisome; Reference proteome; Serine esterase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 432 AA |
Protein Sequence | MHAFTTQNPN RMAPTVILEP AGGCLCDQPV HIAVRGLAPE QPVTLRSVLR DEKGALFRAH 60
ARYRADSHGE LDLARTPALG GSFSGLEPMG LLWAMEPDRP FWRLIKRDVQ TPFVVELEVL 120
DGHEPDGGQR LARAVHERHF MAPGVRRVPV REGRVRATLF LPPGTGPFPG IIDLFGIGSG 180
LLEYRASLLA GKGFAVMALA YNNYEDLPKD MDIIHLEYFE EAVTYLLSHP QVTGSGVGVL 240
GISKGGELGF AMASFLKNIT AAVIINGSIS NIGGNLQYKD ETVPSVGINT KRVKRTKDGL 300
KDIVDLLNNP LEGPDQKSLI PVERSDTAFL FLVGQDDHNW KSEFYAREAS KRLQAHGKEK 360
PQIICYPETG HHIEPPYFPL CKASLNSLVG GPVIWGGEPR AHAMAQVDAW QQLQTFFHNH 420
LDGKKKTIPA KL 432 |
Gene Ontology | GO:0005829; C:cytosol; IDA:MGI. GO:0005777; C:peroxisome; TAS:HGNC. GO:0047617; F:acyl-CoA hydrolase activity; IDA:HGNC. GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:EC. GO:0006637; P:acyl-CoA metabolic process; IDA:HGNC. GO:0001676; P:long-chain fatty acid metabolic process; IDA:HGNC. GO:0032788; P:saturated monocarboxylic acid metabolic process; IDA:HGNC. GO:0032789; P:unsaturated monocarboxylic acid metabolic process; IDA:HGNC. GO:0000038; P:very long-chain fatty acid metabolic process; IDA:HGNC. |
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