CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016849
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription elongation regulator 1 
Protein Synonyms/Alias
 Formin-binding protein 28; FBP 28; TATA box-binding protein-associated factor 2S; Transcription factor CA150; p144 
Gene Name
 Tcerg1 
Gene Synonyms/Alias
 Taf2s 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
446EYKTADGKTYYYNNRubiquitination[1]
755TFSEFAAKHAKDSRFacetylation[2]
994KEDPRCIKFSSSDRKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity). 
Sequence Annotation
 DOMAIN 131 164 WW 1.
 DOMAIN 431 464 WW 2.
 DOMAIN 530 563 WW 3.
 DOMAIN 661 714 FF 1.
 DOMAIN 727 781 FF 2.
 DOMAIN 793 848 FF 3.
 DOMAIN 898 954 FF 4.
 DOMAIN 956 1012 FF 5.
 DOMAIN 1014 1079 FF 6.
 MOTIF 628 632 Nuclear localization signal (Potential).  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1100 AA 
Protein Sequence
MAERGGDGGE GERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP PPFGMMRGPP 60
PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM PPPMGAMPPP PGMMFPPGMP 120
PGTAPGAPAL PPTEEIWVEN KTPDGKVYYY NARTRESAWT KPDGVKVIQQ SELTPMLAAQ 180
AQVQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ 240
AQAQAQAQAQ AQVQAQAVGA PTPTTSSPAP AVSTSTPTST PSSTTATTTT ATSVAQTVST 300
PTTQDQTPSS AVSVATPTVS VSAPAPTATP VQTVPQPHPQ TLPPAVPHSV PQPAAAIPAF 360
PPVMVPPFRV PLPGMPIPLP GVAMMQIVSC PYVKTVATTK TGVLPGMAPP IVPMIHPQVA 420
IAASPATLAG ATAVSEWTEY KTADGKTYYY NNRTLESTWE KPQELKEKEK LDEKIKEPIK 480
EASEEPLPME TEEEDPKEEP VKEIKEEPKE EEMTEEEKAA QKAKPVATTP IPGTPWCVVW 540
TGDERVFFYN PTTRLSMWDR PDDLIGRADV DKIIQEPPHK KGLEDMKKLR HPAPTMLSIQ 600
KWQFSMSAIK EEQELMEEMN EDEPIKAKKR KRDDNKDIDS EKEAAMEAEI KAARERAIVP 660
LEARMKQFKD MLLERGVSAF STWEKELHKI VFDPRYLLLN PKERKQVFDQ YVKTRAEEER 720
REKKNKIMQA KEDFKKMMEE AKFNPRATFS EFAAKHAKDS RFKAIEKMKD REALFNEFVA 780
AARKKEKEDS KTRGEKIKSD FFELLSNHHL DSQSRWSKVK DKVESDPRYK AVDSSSMRED 840
LFKQYIEKIA KNLDSEKEKE LERQARIEAS LREREREVQK ARSEQTKEID REREQHKREE 900
AIQNFKALLS DMVRSSDVSW SDTRRTLRKD HRWESGSLLE REEKEKLFNE HIEALTKKKR 960
EHFRQLLDET SAITLTSTWK EVKKIIKEDP RCIKFSSSDR KKQREFEEYI RDKYITAKAD 1020
FRTLLKETKF ITYRSKKLIQ ESDQHLKDVE KILQNDKRYL VLDCVPEERR KLIVAYVDDL 1080
DRRGPPPPPT ASEPTRRSTK 1100 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0070064; F:proline-rich region binding; IDA:MGI.
 GO:0001106; F:RNA polymerase II transcription corepressor activity; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:MGI.
 GO:0006351; P:transcription, DNA-dependent; ISS:MGI. 
Interpro
 IPR002713; FF_domain.
 IPR001202; WW_dom. 
Pfam
 PF01846; FF
 PF00397; WW 
SMART
 SM00441; FF
 SM00456; WW 
PROSITE
 PS51676; FF
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS