CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014836
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyrroline-5-carboxylate reductase 2 
Protein Synonyms/Alias
 P5C reductase 2; P5CR 2 
Gene Name
 Pycr2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
283KVSPAALKKTLLDRVacetylation[1]
284VSPAALKKTLLDRVKacetylation[1]
307LAPPSSGKLLTRNPAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). 
Sequence Annotation
 NP_BIND 6 11 NADP (By similarity).
 NP_BIND 69 72 NADP (By similarity).
 NP_BIND 95 97 NADP (By similarity).
 BINDING 34 34 NADP; via carbonyl oxygen (By
 BINDING 56 56 NADP (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 304 304 Phosphoserine (By similarity).  
Keyword
 Acetylation; Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein; Proline biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MSVGFIGAGQ LACALARGFT AAGVLSAHKI IASSPEMDLP TVSALRKMGV NLTRSNKDTV 60
RHSDVLFLAV KPHIIPFILD EIGADVQERH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC 120
MTNTPVVVRE GATVYATGTH ALVEDGKLLE QLMSSVGFCT EVEEDLIDAI TGLSGSGPAY 180
AFMALDALAD GGVKMGVPRR LAVRLGAQAL LGAAKMLLDS EDHPGQLKDN VCSPGGATIH 240
ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKVSPA ALKKTLLDRV KLESPTVSTL 300
APPSSGKLLT RNPAQGSKRE 320 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420.
 IPR000304; Pyrroline-COOH_reductase. 
Pfam
 PF03807; F420_oxidored 
SMART
  
PROSITE
 PS00521; P5CR 
PRINTS