CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018099
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WAS/WASL-interacting protein family member 2 
Protein Synonyms/Alias
 WASP-interacting protein-related protein; WIP- and CR16-homologous protein; WIP-related protein 
Gene Name
 WIPF2 
Gene Synonyms/Alias
 WICH; WIRE; PP10631 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66RSAPILEKPKGSSGGacetylation[1]
68APILEKPKGSSGGYGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. 
Sequence Annotation
 DOMAIN 36 53 WH2.
 REGION 49 52 Binds actin (Potential).  
Keyword
 Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MPIPPPPPPP PGPPPPPTFH QANTEQPKLS RDEQRGRGAL LQDICKGTKL KKVTNINDRS 60
APILEKPKGS SGGYGSGGAA LQPKGGLFQG GVLKLRPVGA KDGSENLAGK PALQIPSSRA 120
AAPRPPVSAA SGRPQDDTDS SRASLPELPR MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP 180
PPGRRANAPP TPLPMHSSKA PAYNREKPLP PTPGQRLHPG REGPPAPPPV KPPPSPVNIR 240
TGPSGQSLAP PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT 300
SASPSLLSNR PPPPARDPPS RGAAPPPPPP VIRNGARDAP PPPPPYRMHG SEPPSRGKPP 360
PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY SFHPVEDFPA PEEYKHFQRI 420
YPSKTNRAAR GAPPLPPILR 440 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome. 
Interpro
 IPR003124; WH2_dom. 
Pfam
 PF02205; WH2 
SMART
 SM00246; WH2 
PROSITE
 PS51082; WH2 
PRINTS