CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038901
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP synthase subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Atp5a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
123VVVFGNDKLIKEGDIacetylation[1]
126FGNDKLIKEGDIVKRacetylation[1]
132IKEGDIVKRTGAIVDacetylation[1]
161LGNAIDGKGPVGSKIacetylation[1]
167GKGPVGSKIRRRVGLacetylation[1]
175IRRRVGLKAPGIIPRacetylation[1]
194EPMQTGIKAVDSLVPacetylation[1]
230IDTIINQKRFNDGTDacetylation[1]
239FNDGTDEKKKLYCIYacetylation[1]
240NDGTDEKKKLYCIYVacetylation[1]
261STVAQLVKRLTDADAacetylation[1]
305EYFRDNGKHALIIYDacetylation[1]
316IIYDDLSKQAVAYRQacetylation[1]
427AAQTRAMKQVAGTMKacetylation[1]
434KQVAGTMKLELAQYRacetylation[1]
498GVRGYLDKLEPSKITacetylation[1]
503LDKLEPSKITKFESAacetylation[1]
506LEPSKITKFESAFLSacetylation[1]
531GNIRSDGKISEQSDAacetylation[1]
539ISEQSDAKLKEIVTNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity). 
Sequence Annotation
  
Keyword
 ATP synthesis; ATP-binding; CF(1); Complete proteome; Hydrogen ion transport; Ion transport; Nucleotide-binding; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MLSVRIAAAV ARALPRRAGL VSKNALGSSF VGTRNLHASN TRLQKTGTAE MSSILEERIL 60
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG 120
NDKLIKEGDI VKRTGAIVDV PVGDELLGRV VDALGNAIDG KGPVGSKIRR RVGLKAPGII 180
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGTDEKK 240
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF 300
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDSFG 360
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA 420
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA 480
IEEQVAVIYA GVRGYLDKLE PSKITKFESA FLSHVVSQHQ SLLGNIRSDG KISEQSDAKL 540
KEIVTNFLAG FER 553 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:Compara.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0006629; P:lipid metabolic process; IEA:Compara. 
Interpro
 IPR020003; ATPase_a/bsu_AS.
 IPR004100; ATPase_a/bsu_N.
 IPR005294; ATPase_F1-cplx_asu.
 IPR023366; ATPase_F1/A1-cplx_a_su_N.
 IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C.
 IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00006; ATP-synt_ab
 PF00306; ATP-synt_ab_C
 PF02874; ATP-synt_ab_N 
SMART
  
PROSITE
 PS00152; ATPASE_ALPHA_BETA 
PRINTS