CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Numa1 
Protein Synonyms/Alias
  
Gene Name
 Numa1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
245SLKLLTEKDAQIAMMubiquitination[1]
295VRLHETLKQCQNLKTacetylation[2]
377DKKCLEEKNEILQGKacetylation[2]
443TLECERGKQEAQLLAacetylation[3]
1471ELDQAREKYVQELAAubiquitination[1]
1507ELEVMTAKYEGAKVKacetylation[2]
1681QQLRDLGKFQVATDAacetylation[2, 3]
1748ISQRLPPKVESLESLacetylation[2]
2040SILNTPKKLGNSLLRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2094 AA 
Protein Sequence
MTLHATRAAT LLSWVNSLHV ADPVETVLQL QDCSIFIKII NTIHDTKEGQ QILQQPLPER 60
LDFVCSFLQK NRKHPSSTQC LVSVQKVIEG SEMELAKMIM LFLYQSTMSS RNLRDWEQFE 120
YGVQAELAVI LKFMLDHEES LNLTEDLESF LEKVPYTHAS TLSEELSPPS HQTKRKIRFL 180
EIQRIASSSS ENNFLSGSPS SPMGDILQTP QFQMRRLKKQ LADERSNRDD LELELSESLK 240
LLTEKDAQIA MMQQRIDHLA LLNEKQAASS QEPSELEELR GKNESLTVRL HETLKQCQNL 300
KTEKSQMDRK ISQLSEENGD LSFKVREFAN HLQQLQGAFN DLIEEHSKAS QEWAEKQARL 360
ENELSTALQD KKCLEEKNEI LQGKLSQLED QATRLQESPA PEKGEVLGDA LQLDTLKQEA 420
AKLATDNTQL QTRVETLECE RGKQEAQLLA ERSRFEDEKQ QLASLIADLQ SSVSNLSQAK 480
EELEQASQAQ GAQLTAQLTS MTGLNATLQQ RDQELASLKE QAKKEQAQML QTMQEQEQAA 540
QGLRQQVEQL SSSLKLKEQQ LEEAAKEQEA TRQDHAQQLA IVAEAREASL RERDTARQQL 600
ETVEKEKDAK LESLQQQLQA ANDARDNAQT SVTQAQQEKA ELSQKIGELH ACIEASHQEQ 660
RQVQARVTEL EAQLKAEQQK TTEREKVVQE KAQLQEQLRA LEESLKITKG SLEEEKRRAA 720
DALKEQQCRA TEMEAESRSL MEQREREQKE LEQEKAGRKG LEARIQQLEE AHQAETEALR 780
HELAEATASQ HRAESECERL IREVESRQKR FEARQQEEAR YGAMFQEQLM ALKGEKTGQE 840
VQEEAVEIHS EGQPGQQQSQ LAQLHASLAK AIQQVQEKEV RAQKLVDDLS ALQEKMAATN 900
KEVACLKTLV LKAGEQQETA SLELLKEPPR AANRASDQLG EQQGRPFSST HAAVKAMERE 960
AEQMGGELER LRAALIKSQG QQQEERGQQE REVARLTQER GQAQADLAQE KAAKAELEMR 1020
LQNTLNEQRV EFAALQEALA HALTEKEGTD QELAKLRGQE AAQRTELKEL QQTLEQLKIQ 1080
LVKKEKEHPA GGASGEDASG PGTQSETAGK TDAPGPELQA LRAEISKLEQ QCQQQQQQVE 1140
GLTHSLKSER ACRAEQDKAL ETLQGQLEEK ARELGHNQAA SASAQRELQA LRAKAQDHSK 1200
AEEEWKAQVA RGQQEAERKS SLISSLEEEV SILNRQVLEK EGESKELKRL VVAESEKSQK 1260
LEERLRLLQV ETASNSARAA ERSSALREEV QSLREEVEKQ RVVSENSRQE LASQAERAEE 1320
LGQELKAWQE KFFQKEQALS ALQLEHTSTQ ALVSELLPAK HLCQQLQAEQ AAAEKRFREE 1380
LEQSKQAAGG LQAELMRAQR ELGELGSLRQ KIVEQERAAQ QLRAEKASYA EQLSMLKKAH 1440
GLLAEENRGL GERANLGRQF LEVELDQARE KYVQELAAVR TDAETHLAEM RQEAQSTSRE 1500
LEVMTAKYEG AKVKVLEERQ RFQEERQKLT AQVEELSKKL TEHDQASKVQ QQKLKAFQAQ 1560
RGESQQEVQR LQTQLNELQA QLSQKEQAAE HYKLQMEKAK THYDAKKQQN QKLQEQLQDL 1620
EELQKENKEL RSEAERLGRE LQQAGLKTKE AEQTCRHLTA QVRSLEAQVA HADQQLRDLG 1680
KFQVATDALK SREPQVKPQL DLSIDSLDLS LEEGTPCSVA SKLPRTQPDG TSVPGEPASP 1740
ISQRLPPKVE SLESLYFTPT PARGQAPLET SLDSLGDAFP DSGRKTRSAR RRTTQIINIT 1800
MTKKLELEEP DSANSSFYST QSAPASQANL RATSSTQSLA RLGSPDDGNS ALLSLPGYRP 1860
TTRSSARRSQ ARMSSGAPQG RNSFYMGTCQ DEPEQLDDWN RIAELQQRNR VCPPHLKTCY 1920
PLESRPTLSL ATITDEEMKT GDPRETLRRA SMQPAQIAEG VGITTRQQRK RVSSETHQGP 1980
GTPESKKATS CFPRPMTPRD RHEGRKQSST ADTQKKAAPV LKQADRRQSM AFSILNTPKK 2040
LGNSLLRRGA SKKTPAKVSP NPRSGTRRSP RIATTTTGTA TVATTPRAKG KVKH 2094 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:Compara.
 GO:0000132; P:establishment of mitotic spindle orientation; IMP:MGI.
 GO:0060487; P:lung epithelial cell differentiation; IMP:MGI. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS