| Tag | Content |
|---|
| CPLM ID | CPLM-010685 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Survival motor neuron protein |
Protein Synonyms/Alias | |
Gene Name | Smn1 |
Gene Synonyms/Alias | Smn |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 42 | ALIKAYDKAVASFKH | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs (By similarity). |
Sequence Annotation | DOMAIN 88 148 Tudor.
REGION 274 288 Required for interaction with SYNCRIP (By
MOD_RES 5 5 Phosphoserine (By similarity).
MOD_RES 22 22 Phosphothreonine (By similarity).
MOD_RES 25 25 Phosphoserine.
MOD_RES 28 28 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 288 AA |
Protein Sequence | MAMGSGGAGS EQEDTVLFRR GTGQSDDSDI WDDTALIKAY DKAVASFKHA LKNGDICETP 60
DKPKGTARRK PAKKNKSQKK NATTPLKQWK VGDKCSAVWS EDGCIYPATI TSIDFKRETC 120
VVVYTGYGNR EEQNLSDLLS PTCEVANSTE QNTQENESQV STDDSEHSSR SLRSKAHSKS 180
KAAPWTSFLP PPPPMPGSGL GPGKPGLKFN GPPPPPPLPP PPFLPCWMPP FPSGPPIIPP 240
PPPISPDCLD DTDALGSMLI SWYMSGYHTG YYMGFRQNKK EGKCSHTN 288 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |