| Tag | Content |
|---|
| CPLM ID | CPLM-010844 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenylate cyclase type 6 |
Protein Synonyms/Alias | ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase |
Gene Name | Adcy6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 127 | LVQVFQSKQFRSAKL | ubiquitination | [1] | | 411 | ELFARFDKLAAENHC | ubiquitination | [1] | | 565 | EEKAMLAKLQRTRAN | ubiquitination | [1] | | 606 | MGIDDSSKDNRGAQD | ubiquitination | [1] | | 931 | KLQATGEKEEMEELQ | ubiquitination | [1] | | 1098 | AGVIGARKPQYDIWG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Membrane-bound, calcium-inhibitable adenylyl cyclase. |
Sequence Annotation | METAL 382 382 Magnesium 1 (By similarity).
METAL 382 382 Magnesium 2 (By similarity).
METAL 383 383 Magnesium 2; via carbonyl oxygen (By
METAL 426 426 Magnesium 1 (By similarity).
METAL 426 426 Magnesium 2 (By similarity).
MOD_RES 553 553 Phosphoserine (By similarity).
MOD_RES 573 573 Phosphoserine (By similarity).
MOD_RES 659 659 Phosphoserine (By similarity).
MOD_RES 916 916 Phosphothreonine (By similarity).
CARBOHYD 277 277 N-linked (GlcNAc...) (Potential).
CARBOHYD 790 790 N-linked (GlcNAc...) (Potential).
CARBOHYD 875 875 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; cAMP biosynthesis; Cell projection; Cilium; Complete proteome; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1165 AA |
Protein Sequence | MSWFSGLLVP KVDERKTAWG ERNGQKRPRH ANRASGFCAP RYMSCLKNAE PPSPTPAAHT 60
RCPWQDEAFI RRAGPGRGVE LGLRSVALGF DDTEVTTPMG TAEVAPDTSP RSGPSCWHRL 120
VQVFQSKQFR SAKLERLYQR YFFQMNQSSL TLLMAVLVLL MAVLLTFHAA PAQPQPAYVA 180
LLTCASVLFV VLMVVCNRHS FRQDSMWVVS YVVLGILAAV QVGGALAANP HSPSAGLWCP 240
VFFVYITYTL LPIRMRAAVL SGLGLSTLHL ILAWQLNSSD PFLWKQLGAN VVLFLCTNAI 300
GVCTHYPAEV SQRQAFQETR GYIQARLHLQ HENRQQERLL LSVLPQHVAM EMKEDINTKK 360
EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM TLNELFARFD KLAAENHCLR 420
IKILGDCYYC VSGLPEARAD HAHCCVEMGV DMIEAISLVR EVTGVNVNMR VGIHSGRVHC 480
GVLGLRKWQF DVWSNDVTLA NHMEAGGGRR IHITRATLQY LNGDYEVEPG RGGERNAYLK 540
EQCIETFLIL GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 600
IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ REDLEKKYSR 660
KVDPRFGAYV ACALLVFCFI CFIQLLVFPY STLILGIYAA IFLLLLVTVL ICAVCSCGSF 720
FPKALQRLSR NIVRSRVHST AVGIFSVLLV FISAIANMFT CNHTPIRTCA ARMLNLTPAD 780
VTACHLQQLN YSLGLDAPLC EGTAPTCSFP EYFVGNVLLS LLASSVFLHI SSIGKLAMTF 840
ILGFTYLVLL LLGPPAAIFD NYDLLLGVHG LASSNETFDG LDCPAVGRVA LKYMTPVILL 900
VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP KDVAAHFLAR 960
ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE CLRLLNEIIA DFDEIISEER 1020
FRQLEKIKTI GSTYMAASGL NASTYDQVGR SHITALADYA MRLMEQMKHI NEHSFNNFQM 1080
KIGLNMGPVV AGVIGARKPQ YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKGYQL 1140
ECRGVVKVKG KGEMTTYFLN GGPSS 1165 |
Gene Ontology | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:MGI. GO:0004016; F:adenylate cyclase activity; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0019901; F:protein kinase binding; ISS:BHF-UCL. GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI. GO:0035556; P:intracellular signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |