| Tag | Content |
|---|
| CPLM ID | CPLM-008243 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Prohibitin-2 |
Protein Synonyms/Alias | |
Gene Name | PHB2 |
Gene Synonyms/Alias | YGR231C; G8561 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 21 | AFQKQLSKVQQTGGR | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. |
Sequence Annotation | |
Keyword | Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 310 AA |
Protein Sequence | MNRSPGEFQR YAKAFQKQLS KVQQTGGRGQ VPSPRGAFAG LGGLLLLGGG ALFINNALFN 60
VDGGHRAIVY SRIHGVSSRI FNEGTHFIFP WLDTPIIYDV RAKPRNVASL TGTKDLQMVN 120
ITCRVLSRPD VVQLPTIYRT LGQDYDERVL PSIVNEVLKA VVAQFNASQL ITQREKVSRL 180
IRENLVRRAS KFNILLDDVS ITYMTFSPEF TNAVEAKQIA QQDAQRAAFV VDKARQEKQG 240
MVVRAQGEAK SAELIGEAIK KSRDYVELKR LDTARDIAKI LASSPNRVIL DNEALLLNTV 300
VDARIDGRGK 310 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IDA:SGD. GO:0000001; P:mitochondrion inheritance; IMP:SGD. GO:0045861; P:negative regulation of proteolysis; IPI:SGD. GO:0006457; P:protein folding; IPI:SGD. GO:0001302; P:replicative cell aging; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |