| Tag | Content |
|---|
| CPLM ID | CPLM-020328 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serrate RNA effector molecule homolog |
Protein Synonyms/Alias | Arsenite-resistance protein 2 |
Gene Name | SRRT |
Gene Synonyms/Alias | ARS2; ASR2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 476 | FDRSVNIKEICWNLQ | ubiquitination | [1] |
|
Reference | [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylglycine.
MOD_RES 4 4 Phosphoserine.
MOD_RES 8 8 Phosphotyrosine.
MOD_RES 74 74 Phosphoserine.
MOD_RES 493 493 Phosphoserine.
MOD_RES 540 540 Phosphoserine.
MOD_RES 544 544 Phosphothreonine. |
Keyword | Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 876 AA |
Protein Sequence | MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR 60
NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY AGGGGGPTYG PPQPWGHPDV 120
HIMQHHVLPI QARLGSIAEI DLGVPPPVMK TFKEFLLSLD DSVDETEAVK RYNDYKLDFR 180
RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI 240
DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER 300
KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK KRNRKHSGDD 360
SFDEGSVSES ESESESGQAE EEKEEAEEAL KEKEKPKEEE WEKPKDAAGL ECKPRPLHKT 420
CSLFMRNIAP NISRAEIISL CKRYPGFMRV ALSEPQPERR FFRRGWVTFD RSVNIKEICW 480
NLQNIRLREC ELSPGVNRDL TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS 540
EPGTPPLPTS LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE 600
RDEKLIKVLD KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP PNRISHGEVL 660
EWQKTFEEKL TPLLSVRESL SEEEAQKMGR KDPEQEVEKF VTSNTQELGK DKWLCPLSGK 720
KFKGPEFVRK HIFNKHAEKI EEVKKEVAFF NNFLTDAKRP ALPEIKPAQP PGPAQSLTPG 780
LPYPHQTPQG LMPYGQPRPP ILGYGAGAVR PAVPTGGPPY PHAPYGAGRG NYDAFRGQGG 840
YPGKPRNRMV RGDPRAIVEY RDLDAPDDVD FF 872 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005654; C:nucleoplasm; ISS:UniProtKB. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0008283; P:cell proliferation; ISS:UniProtKB. GO:0097150; P:neuronal stem cell maintenance; ISS:UniProtKB. GO:0031053; P:primary miRNA processing; IMP:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0046685; P:response to arsenic-containing substance; NAS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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