CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041821
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG115964 
Protein Synonyms/Alias
 WD repeat-containing protein 70 
Gene Name
 Wdr70 
Gene Synonyms/Alias
 mCG_115964 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
455QRGCGSGKLVFLERRacetylation[1, 2, 3]
512NKSQRGAKLCVVKTQacetylation[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MEHSGTSEVT GADTAGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA VERSRKTLEA 60
REKEEEMNRE KELRKQIEDM EPAPSSSSAA RERSQSSCRD TSSSDSESDD SSDSSDDELI 120
GPPLPPKMVG ESVTTVDEGT LGPLPPPLCE EGEDDDDDEL DDEGEEDNPV QRIPDSHEIT 180
LRHGTKTVSA LGLDPSGARL VTGGYDYDVK FWDFAGMDAS FKAFRSLQPC ECHQIKSLQY 240
SNTGDMILVV SGSSQAKVID RDGFEVMECI KGDQYIVDMA NTKGHTAMLH TGSWHPKIKG 300
EFMTCSNDAT VRLWEVENPK KQKSVFKPRT MQGKKVIPTT CTYSRDGNLV AAACQNGSIQ 360
IWDRNLTVHP KFHYKQAHDP GTDTSCVAFS YDGNVLASRG GDDTLKLWDV RQFNKPLFSA 420
SDLPTLFPMT DCCFSPDDKL IVTGTSVQRG CGSGKLVFLE RRTFQRVYEI HITDASVVRC 480
LWHPKLNQIM VGTGNGLAKV YYDPNKSQRG AKLCVVKTQR KAKQAETLTQ DYIITPHALP 540
MFREPRQRST RKQLEKDRLD PLKSHKPEPP VAGPGRGGRV GTHGGTLSSY IVKNIALDKT 600
DDSNPREAIL RHAKAAEDNP YWVSPAYSKT QPKTMFAQVE SDDEESKNEP EWKKRKI 657 
Gene Ontology
  
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.