UniProt Accession

 CRTC2_HUMAN; Q53ET0; Q6UUV8; Q7Z3X7 

Genbank Protein ID

 AY360172; AK223559; AL358472; BC053562 

Genbank Nucleotide ID

 AAQ98857.1; BAD97279.1; CAI14017.1; AAH53562.1 

Protein Name

 CREB-regulated transcription coactivator 2 

Protein Synonyms/Alias

 Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2 

Gene Name

 CRTC2 

Gene Synonyms/Alias

 TORC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
156	WGNFPAEKGQLFRLP	ubiquitination	[1, 2]
228	LDDKHLLKPWDAKKL	acetylation	[3]
629	DSSPGFSKEIAAALA	acetylation	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.
 Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.
 Nature. 2008 Nov 13;456(7219):269-73. [PMID: 18849969] 

Functional Description

 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). 

Sequence Annotation

 MOTIF 271 287 Nuclear export signal (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 70 70 Phosphoserine.
 MOD_RES 86 86 Phosphoserine.
 MOD_RES 90 90 Phosphoserine.
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 169 169 Phosphothreonine (By similarity).
 MOD_RES 171 171 Phosphoserine; by AMPK, MARK2, SIK1 and
 MOD_RES 177 177 Phosphothreonine (By similarity).
 MOD_RES 192 192 Phosphothreonine.
 MOD_RES 274 274 Phosphoserine; by MARK2.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 433 433 Phosphoserine.
 MOD_RES 456 456 Phosphoserine.
 MOD_RES 488 488 Phosphotyrosine.
 MOD_RES 489 489 Phosphoserine.
 MOD_RES 490 490 Phosphoserine.
 MOD_RES 492 492 Phosphoserine.
 MOD_RES 501 501 Phosphothreonine.
 MOD_RES 613 613 Phosphoserine.
 MOD_RES 624 624 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Activator; Complete proteome; Cytoplasm; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 693 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008140; F:cAMP response element binding protein binding; IEA:InterPro.
 GO:0006094; P:gluconeogenesis; ISS:UniProtKB.
 GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
 GO:0032793; P:positive regulation of CREB transcription factor activity; ISS:UniProtKB.
 GO:0051289; P:protein homotetramerization; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR024786; TORC.
 IPR024785; TORC_C.
 IPR024784; TORC_M.
 IPR024783; TORC_N. 

Pfam

 PF12886; TORC_C
 PF12885; TORC_M
 PF12884; TORC_N 

SMART

  

PROSITE

  

PRINTS