UniProt Accession

 KCY_RAT; Q4KM73 

Genbank Protein ID

 BC098727 

Genbank Nucleotide ID

 AAH98727.1 

Protein Name

 UMP-CMP kinase 

Protein Synonyms/Alias

 Deoxycytidylate kinase; CK; dCMP kinase; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPK 

Gene Name

 Cmpk1 

Gene Synonyms/Alias

 Cmpk 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
26	QCARIVEKYGYTHLS	acetylation	[1]
43	ELLRDERKNPDSQYG	acetylation	[1]
43	ELLRDERKNPDSQYG	ubiquitination	[2]
55	QYGELIEKYIKEGKI	acetylation	[1]
150	DNRESLEKRIQTYLE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors (By similarity). 

Sequence Annotation

 NP_BIND 13 18 ATP (By similarity).
 NP_BIND 61 63 NMP (By similarity).
 NP_BIND 93 96 NMP (By similarity).
 REGION 33 63 NMPbind (By similarity).
 REGION 133 143 LID (By similarity).
 BINDING 39 39 NMP (By similarity).
 BINDING 100 100 CMP (By similarity).
 BINDING 134 134 ATP (By similarity).
 BINDING 140 140 NMP (By similarity).
 BINDING 151 151 NMP (By similarity).
 BINDING 179 179 ATP; via carbonyl oxygen (By similarity).
 MOD_RES 55 55 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Pyrimidine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004127; F:cytidylate kinase activity; IEA:EC.
 GO:0033862; F:UMP kinase activity; IDA:RGD.
 GO:0046705; P:CDP biosynthetic process; IDA:RGD.
 GO:0006240; P:dCDP biosynthetic process; IDA:RGD.
 GO:0006227; P:dUDP biosynthetic process; IDA:RGD.
 GO:0022602; P:ovulation cycle process; IEP:RGD.
 GO:0018963; P:phthalate metabolic process; IEP:RGD.
 GO:0006225; P:UDP biosynthetic process; IDA:RGD. 

Interpro

 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase.
 IPR006266; UMP_CMP_kinase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.