UniProt Accession

 I13R1_HUMAN; P78552; O95646; Q5JSL4; Q99656 

Genbank Protein ID

 Y10659; Y09328; U62858; U81379; AK313467; AL391280; CH471161; BC009960 

Genbank Nucleotide ID

 CAA71669.1; CAA70508.1; AAB37127.1; AAD00510.3; BAG36253.1; CAI41410.1; EAW89893.1; AAH09960.1 

Protein Name

 Interleukin-13 receptor subunit alpha-1 

Protein Synonyms/Alias

 IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD213a1 

Gene Name

 IL13RA1 

Gene Synonyms/Alias

 IL13R; IL13RA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
386	PDPGKIFKEMFGDQN	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. 

Sequence Annotation

 MOTIF 327 331 WSXWS motif.
 MOTIF 374 382 Box 1 motif.
 CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 105 105 N-linked (GlcNAc...) (Potential).
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
 CARBOHYD 235 235 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
 CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
 CARBOHYD 329 329 N-linked (GlcNAc...) (Potential).
 CARBOHYD 341 341 N-linked (GlcNAc...) (Potential).
 DISULFID 62 102
 DISULFID 95 117
 DISULFID 134 144
 DISULFID 173 185
 DISULFID 257 320
 DISULFID 282 296  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 427 AA 

Protein Sequence

Gene Ontology

 GO:0005898; C:interleukin-13 receptor complex; TAS:ProtInc.
 GO:0004896; F:cytokine receptor activity; IEA:InterPro.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:GOC. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR015321; IL6_recept-bd.
 IPR003532; Short_hematopoietin_rcpt_2_CS. 

Pfam

 PF09240; IL6Ra-bind 

SMART

  

PROSITE

 PS01356; HEMATOPO_REC_S_F2 

PRINTS