CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DEAH (Asp-Glu-Ala-His) box polypeptide 38 
Protein Synonyms/Alias
 Protein Dhx38 
Gene Name
 Dhx38 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
261RDRSIRSKSSDDTPLacetylation[1]
522EASSEFAKKKSILEQacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1228 AA 
Protein Sequence
MEDPGEDTSI HRLEGTSLDS QVGGLICKTK SAANEQHVFK APAPRPSLLG LDLLASLKRR 60
EREEKDDGED KKKSRVSSYK DWEESKDDQK DAEEESEDQA GRSSRRDRHY RSARVETPSH 120
PGGVSEEFWE RSRQRERDRR EHGVYASSKE EKDRKKERSR DRDYDRKRDR ADERDRSRHS 180
SRSDRDGGSE RSSRRNEPES PRHRPKDAAT PSRSAWEEDD SGYGSSRRSQ WETPSPTPSY 240
RDSERGHRPS TRDRDRSIRS KSSDDTPLPT PSYKYNEWAD DRRHLGSTPR LSRGRGRRED 300
GEEGIAFDTE EERQQWEDDQ RQADRDWYMM DEGYDEFHNP LAYSSEDYVR RREQHLHKQK 360
QKRISAQRRQ INEDNERWET NRMLTSGVVH RLEVDEDFEE DNAAKVHLMV HNLVPPFLDG 420
RIVFTKQPEP VIPVKDATSD LAIIARKGSQ TVRKHREQKE RRKAQHKHWE LAGTKLGDIM 480
GVKKEEEPDK AMTEDGKVDY RTEQKFADHM KEKSEASSEF AKKKSILEQR QYLPIFAVQQ 540
ELLTIIRDNS IVIVVGETGS GKTTQLTQYL HEDGYTDYGM IGCTQPRRVA AMSVAKRVSE 600
EMGGNLGEEV GYAIRFEDCT SENTLIKYMT DGILLRESLR EADLDHYSAV IMDEAHERSL 660
NTDVLFGLLR EVVARRSDLK LIVTSATMDA EKFAAFFGNV PIFHIPGRTF PVDILFSKTP 720
QEDYVEAAVK QSLQVHLSGA PGDILIFMPG QEDIEVTSDQ IVEHLEELEN APALAVLPIY 780
SQLPSDLQAK IFQKAPDGVR KCIVATNIAE TSLTVDGIMF VIDSGYCKLK VFNPRIGMDA 840
LQIYPISQAN ANQRSGRAGR TGPGQCFRLY TQSAYKNELL TTTVPEIQRT NLANVVLLLK 900
SLGVQDLLQF HFMDPPPEDN MLNSMYQLWI LGALDNTGGL TSTGRLMVEF PLDPALSKML 960
IVSCDMGCSS EILLIVSMLS VPAIFYRPKG REEESDQIRE KFAVPESDHL TYLNVYLQWK 1020
NNNYSTIWCN DHFIHAKAMR KVREVRAQLK DIMVQQRMSL ASCGTDWDIV RKCICAAYFH 1080
QAAKLKGIGE YVNIRTGMPC HLHPTSSLFG MGYTPDYIVY HELVMTTKEY MQCVTAVDGE 1140
WLAELGPMFY SVKQAGKSRQ ENRRRAKEEA SAMEEEMALA EEQLRARRQE QEKRSPLGSV 1200
RSTKIYTPGR KEQGEPMTPR RTPARFGL 1228 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR002464; DNA/RNA_helicase_DEAH_CS.
 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 
SMART
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS00690; DEAH_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS