CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004059
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proteasome subunit alpha type-1 
Protein Synonyms/Alias
 PROS-Dm35; Proteasome 35 kDa subunit 
Gene Name
 Pros35 
Gene Synonyms/Alias
 PROS-35; CG4904 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
174SARTYLEKNLNKFLDacetylation[1]
178YLEKNLNKFLDSSKDacetylation[1]
184NKFLDSSKDEIIRHGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. 
Sequence Annotation
 MOD_RES 103 103 Phosphotyrosine (Potential).  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 279 AA 
Protein Sequence
MFRNQYDSDV TVWSPQGRLH QVEYAMEAVK LGTATVGLKN KDYAVLVALC KPTSELSDTQ 60
RKIIPIDDHL GISIAGLTAD ARVLSRYLRS ECLNYKHSYD TTYPVSRLIT NLGNKMQTTT 120
QRYDRRPYGV GLLVAGYDER GPHIYQVTPS ATFFNCKANS IGSRSQSART YLEKNLNKFL 180
DSSKDEIIRH GIRAILGTLP TDEQGKDAGQ YDITVAIVGK DQPFTILSNK DSAKHVAIAK 240
ENDNDTPRND DDDDRPSPPE EPAAGPRDPE VLVATEQRP 279 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0000502; C:proteasome complex; IDA:FlyBase.
 GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase. 
Interpro
 IPR000426; Proteasome_asu_N.
 IPR023332; Proteasome_suA-type.
 IPR001353; Proteasome_sua/b. 
Pfam
 PF00227; Proteasome
 PF10584; Proteasome_A_N 
SMART
 SM00948; Proteasome_A_N 
PROSITE
 PS00388; PROTEASOME_A_1
 PS51475; PROTEASOME_A_2 
PRINTS