CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017294
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibronectin type III domain-containing protein 5 
Protein Synonyms/Alias
 Fibronectin type III repeat-containing protein 2; Peroxisomal protein; PeP; Irisin 
Gene Name
 Fndc5 
Gene Synonyms/Alias
 Frcp2; Pep 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
189NNNKEKTKSASETSTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 
Sequence Annotation
 DOMAIN 31 121 Fibronectin type-III.
 MOTIF 207 209 Microbody targeting signal (Potential).
 CARBOHYD 36 36 N-linked (GlcNAc...) (Probable).
 CARBOHYD 81 81 N-linked (GlcNAc...) (Probable).  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Glycoprotein; Hormone; Membrane; Peroxisome; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 209 AA 
Protein Sequence
MPPGPCAWPP RAALRLWLGC VCFALVQADS PSAPVNVTVR HLKANSAVVS WDVLEDEVVI 60
GFAISQQKKD VRMLRFIQEV NTTTRSCALW DLEEDTEYIV HVQAISIQGQ SPASEPVLFK 120
TPREAEKMAS KNKDEVTMKE MGRNQQLRTG EVLIIVVVLF MWAGVIALFC RQYDIIKDNE 180
PNNNKEKTKS ASETSTPEHQ GGGLLRSKI 209 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005576; C:extracellular region; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0090336; P:positive regulation of brown fat cell differentiation; IDA:UniProtKB.
 GO:0014850; P:response to muscle activity; IDA:UniProtKB. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold. 
Pfam
 PF00041; fn3 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3 
PRINTS