CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038350
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TBC domain-containing protein kinase-like protein 
Protein Synonyms/Alias
  
Gene Name
 Tbck 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
343LEKELINKEIIRSKPubiquitination[1]
461YKKNQIWKEARVDIPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 893 AA 
Protein Sequence
MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60
RGKHERLVVV AEHCERSLED LLRERKPVSH STVLCIAYEV LEGLHYLNKH GIVHRALSPH 120
NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIPKTT DHVPSEKPLP 180
SGPKSDVWSL GIILFELCVG RKLFQSLDVS ERVKFLLTLG CVDDTIIVLA EEHGCLDIIK 240
ELPENVINIL KKCLTFHPSK RPTPDELMKD QVFSEVSPLY TPFIKPASLF SSSLRCADLT 300
LPEDISDLCK DIDNDYLAER SIEEVYYLWC LAGGDLEKEL INKEIIRSKP PVCTLPNFLF 360
EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420
SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480
GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540
DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600
IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660
AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESVNL FCWTPKSATY RQHAQPPKPA 720
SESSVVRSSA PYFSAECTDP PKTDLSRESI PLSDLKSEVS PRISAEDLID LCELTVTGHF 780
KTPTKKTKSS KPKLLVVDIR NSEDFVRGHI AGSINIPFSA AFTAEGELSQ GPYTTMLHNF 840
KGKVIVVVGH VAKQTAEFAA HLVKMKYPRV CILDGGINKI RPTGLLTVPS PQI 893 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR000195; Rab-GTPase-TBC_dom.
 IPR001763; Rhodanese-like_dom. 
Pfam
 PF00069; Pkinase
 PF00566; RabGAP-TBC
 PF00581; Rhodanese 
SMART
 SM00450; RHOD
 SM00164; TBC 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS50206; RHODANESE_3
 PS50086; TBC_RABGAP 
PRINTS