CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028946
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein CASC5 
Protein Synonyms/Alias
  
Gene Name
 Casc5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
204IKRLKTGKHISSSTEacetylation[1]
1773DYSDEELKNYGIYLNacetylation[2]
1773DYSDEELKNYGIYLNsuccinylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2119 AA 
Protein Sequence
MDGVYSEANE ENDNTQRPVR RQHSSILKPP RSPLQDLKCG NQTNQEPNPP RKRKSSRRVS 60
FADTIKVFQT ESHMKTERNS EISGMNTLLC APIQTQMQQK EFSITDCNHE RKHANDQTVI 120
FSDENQMDLT ASHTVMITKG LSDCTKNENS TKIDTTSFLE NLKHHAANSR IKKDLACSTV 180
SLSQNIFSEK INSDNFIKRL KTGKHISSST ELDKENAEIP VYSKDSNSAS STYQMHASLG 240
VDENSSNRTR IFREQDDGMN LTQCHTACIK TWIPPSTEAK IGEFKGDKTI YGNECMELTT 300
NYTIQVLSSE NNLSERETQT QNGMNVTTVD GATAPAPEKK TALKDKLNAA FQGSFPNPEN 360
KIHIIKCHPI ESETHTVTQI SSQSASTLAV TSKSICSSPA IEGYKTIFHS SSNDAMELTK 420
CLSAMEEEKK LLKADDKYSK ICTNPDAGPL REKTIYLEED SMDITKSHTV AIDNKIFKHD 480
QENIKKEIIA IPIFEKEMVL RNLMPMSKDE KRDVNYISVP QVSKESLQRS QTNTLSVSLT 540
DKKMEFLADE DMDLTKSHTT KLSQVIPTTF DLASKNVTKS YSHSKSPLNE WESLDKQVVL 600
GQHSKLPLPQ RKDRDDPDCS HHKIMYSEEL QTMDLTKSHT IVIGFGPSEV QEHSKINLEH 660
KNSQLTAESI QTAVNVPAAN SRVVTTNDMD MLKDRSTHKP ELLKEKQNIK IYGRKSIGRL 720
KIDKTILFSE GNEGDMDITK SCTVKINHRS LLDKHDSHLV SLAGTSKTIL HARGQVEMEI 780
NRSHTTPLEC KIISPSDITP GDLDKTMMSI DDHEELDMTK SHTVFIDYQA EAKGVLPDRL 840
DFQLSKKESL QKPKVTSLAE EIYISKNSES NHLPAKGSQL TILEEGSNSG LGEETNDAQK 900
PGFLNELLSG KTQRRKSLSL KNKSITFPEN DKSYREIPQS SAVEINNETR LEDRKGFSFV 960
PLAGTSKPVL SAYGPEDMEI SIGQTTASEY KTVPPEEITT IPMDKTVMFV DNFGDLDVTR 1020
SHTVFIDCQA KEKVLDEYTN LGIQKTKTLS GSEGDTHIQE ITKNPAAQHK HHMTTVIPSS 1080
TVVSDQSSMK IKFHKADRDE EVKGKEVEAN MLKQTKPESC LLNITDGKNV DFTSSYTADV 1140
CRSSDKYSSL PNISSSDNSG GNTMSLCDKN KEKAYNCQVP NEFTYAAILP STYHMDSKKL 1200
SVFPPCPSKE VTQTESAIAL LKDEDPVEEP LGEMATFNSK HVSLNLAKDQ TEAFVDVSVA 1260
SQPHLSAQQS PSTQKGQDVA RRDEGILAKA GKKALPFLLE NVAASTWENE SKIPTNVEHF 1320
AVTYEKELSI SIQTDKCNTN VQSPSNSALT TQVIQTHANA EGALDFLVPS TVSCFSSTKP 1380
SLSNLNRKTE EVLDFQTVNL LPPAEQLLEE GSQAHSMSIV QATEIYRLGS RNDRDEESKT 1440
FCNEAETTSV PLKTAVKDKT RRCSLGIFLP KLPSKRSCSI TGVDDLEQIL ADAADLTQLE 1500
TQPVCSKDPG IGSVAAKLNL SPSQFINEEN LPVYPGEILS SDSVSLDIEE SVLIDTSQRE 1560
SLPSENKTEN CRAQKRTRVE ENDVTNEKKI RTHDSAQDQE IFDNHMEEDI NKNVNSVLLK 1620
SLSRTPSSCS SSLDSIKSDG LSLDVSTQRN SQMESQFLGD TISEESLKEK LKDGQITIKE 1680
FFILLQVHIL IQKPRQSTLP AKFTINTLPT TEDLMLRQYV YGPRIQIYKE DCELLRQKID 1740
ELKISALNQN KLLADVNRNL WEKVKDYSDE ELKNYGIYLN KIKSRYTKMT KVFNHQGKVA 1800
LYNKLVHSAE NEKNKLQIKI NEMDTILKKI NNCLAEVETE TKNLENEEKN DAMEEWDSEM 1860
RDAEKELEQL KTEEEELQRK FLEVETQKTQ TLAQIEFIKE QTTKTEELLD QLSLSEWDVI 1920
EWSDDQAVFT FVYDSIELII TFGEPLVGLP FLDKACRKIN ALSFQSLLDE DKAPPSSLLV 1980
HKLIFQYIEE QESWKKKCTA QHQVPQMLQE LSLVVNHCRL LGEEIEFLKR WGPNYSLMHI 2040
NVNNTELRLL FSSCAAFAKF EITLSPSAHY PLVPLPFTIH NHIGKTGHDE IAAIISKVPL 2100
EENYLKNVVK QIYQDLLKD 2119 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008608; P:attachment of spindle microtubules to kinetochore; IEA:Compara.
 GO:0010923; P:negative regulation of phosphatase activity; IEA:Compara.
 GO:0034501; P:protein localization to kinetochore; IEA:Compara.
 GO:0071173; P:spindle assembly checkpoint; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS