| Tag | Content |
|---|
| CPLM ID | CPLM-024378 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosomal biogenesis protein LAS1L |
Protein Synonyms/Alias | Protein LAS1 homolog |
Gene Name | Las1l |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 14 | AWDGQSFKENQPESP | ubiquitination | [1] | | 483 | LPDEEQEKLLRVCSI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. |
Sequence Annotation | MOD_RES 509 509 Phosphoserine (By similarity).
MOD_RES 658 658 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 776 AA |
Protein Sequence | MDRVWRAWDG QSFKENQPES PSARGIVVSW LSRAEWEQVT VYLFCDDHKL QQYALNRITV 60
WRSRLGNELP LAVASTADLV RCKLIDAAGT LGTDELRLLY GMALVRFVNL ISERKTKCSN 120
LPLKYLAQEV NIPDWIVELR HNLTHKKMPH INECRRGCYF VLNWLQKTYW SRQLEGSLKE 180
TWELDEDQLD AEDPEEEERE IIADDVLEEI PEPQDDDKDE ELAVEDDANT KGNEEVASHP 240
EPSSRHKELY EKARELLVSY EEEQFKVLEK HRHLLQAIKV WNNLSPRVQC ILEELKSISW 300
ENRDAVLDAF LDDGFLIPTF EQLAALQIEY EDGQTEVQKG EVTEPNSHKN IDLNEVLVPK 360
PFSQFWQPLL RGLHSQTFTQ ALLERMFSEL STVGSTGIRP TYILRWTVEL IVANTKTGRN 420
ARRFSASQWE ARKSWRLFNC SATLDWPQVI ESCLGSPCWA SPQLLQVVFK AMGQVLPDEE 480
QEKLLRVCSI YTQNGENGLA KAIEGSSSSS TGKAPYTLDT LHEDLQPPGT NCESEESIQQ 540
KEQGNLKDVK QEEKKENEEE EKEEEEMEEE EEEEEEEKEE EEEEQEQEEH QEEEQEEEEE 600
EENQKVFQDQ MEADVEESDD VEEEEEVDDE EEDEDDDYDD DEEEDRMEVG AFSLAQGSSV 660
FENTRTTSRK REALQGSAWQ VSSEDVRWGT FPLGRLPGQT EDPAELMLDN YDTMYLLDQP 720
VIEHRLEPQK SKSSTLSLCC GGSNTNSSSS SSSGNMEGLL WNQGQMHGLK AGLQLF 776 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |