CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015374
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 
Protein Synonyms/Alias
 60 kDa BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; BAF60C 
Gene Name
 SMARCD3 
Gene Synonyms/Alias
 BAF60C 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
189WELRVEGKLLDDPSKubiquitination[1]
196KLLDDPSKQKRKFSSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). 
Sequence Annotation
 DOMAIN 259 334 SWIB.
 MOD_RES 178 178 Phosphoserine.  
Keyword
 Alternative splicing; Chromatin regulator; Complete proteome; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 483 AA 
Protein Sequence
MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY MGSPAVRPGL 60
APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR RKMADKILPQ RIRELVPESQ 120
AYMDLLAFER KLDQTIMRKR VDIQEALKRP MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA 180
SWELRVEGKL LDDPSKQKRK FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV 240
KRPGDLSVRC TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH 300
DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS DQKKTACYDI 360
DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN QLKIQRDFML SFSRDPKGYV 420
QDLLRSQSRD LKVMTDVAGN PEEERRAEFY HQPWSQEAVS RYFYCKIQQR RQELEQSLVV 480
RNT 483 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0071565; C:nBAF complex; ISS:UniProtKB.
 GO:0071564; C:npBAF complex; ISS:UniProtKB.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0016514; C:SWI/SNF complex; NAS:UniProtKB.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IMP:BHF-UCL.
 GO:0003713; F:transcription coactivator activity; NAS:BHF-UCL.
 GO:0003219; P:cardiac right ventricle formation; IEA:Compara.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0006338; P:chromatin remodeling; IDA:BHF-UCL.
 GO:0042692; P:muscle cell differentiation; IEA:Compara.
 GO:0003407; P:neural retina development; IEP:BHF-UCL.
 GO:0006337; P:nucleosome disassembly; IDA:BHF-UCL.
 GO:0002052; P:positive regulation of neuroblast proliferation; IDA:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0043393; P:regulation of protein binding; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0003139; P:secondary heart field specification; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006351; P:transcription, DNA-dependent; IDA:UniProtKB. 
Interpro
 IPR019835; SWIB_domain.
 IPR003121; SWIB_MDM2_domain. 
Pfam
 PF02201; SWIB 
SMART
 SM00151; SWIB 
PROSITE
  
PRINTS