UniProt Accession

 SCN2B_RAT; P54900 

Genbank Protein ID

 U37026 

Genbank Nucleotide ID

 AAC52967.1 

Protein Name

 Sodium channel subunit beta-2 

Protein Synonyms/Alias

  

Gene Name

 Scn2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
197	KLSTDDLKTEEEGKT	ubiquitination	[1]
203	LKTEEEGKTDGEGNA	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. 

Sequence Annotation

 DOMAIN 32 154 Ig-like C2-type.
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 DISULFID 50 127 By similarity.
 DISULFID 55 55 Interchain; with alpha subunit (By  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Signal; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0001518; C:voltage-gated sodium channel complex; TAS:RGD.
 GO:0017080; F:sodium channel regulator activity; IEA:Compara.
 GO:0005248; F:voltage-gated sodium channel activity; IDA:RGD.
 GO:0086006; F:voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0007399; P:nervous system development; IEP:RGD.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0086002; P:regulation of cardiac muscle cell action potential involved in contraction; IEA:Compara.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0046684; P:response to pyrethroid; IDA:RGD. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR000920; Myelin_P0. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS

 PR00213; MYELINP0.